Regulation of immune responses through CD39 and CD73 in cancer: Novel checkpoints

被引:35
作者
Baghbani, Elham [1 ,2 ]
Noorolyai, Saeed [1 ]
Shanehbandi, Dariush [1 ]
Mokhtarzadeh, Ahad [1 ]
Aghebati-Maleki, Leili [1 ]
Shahgoli, Vahid Khaze [1 ,3 ]
Brunetti, Oronzo [4 ]
Rahmani, Shima [1 ]
Shadbad, Mahdi Abdoli [1 ,2 ]
Baghbanzadeh, Amir [1 ]
Silvestris, Nicola [5 ,6 ]
Baradaran, Behzad [1 ]
机构
[1] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran
[2] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran
[3] Univ Southern Denmark, Dept Mol Med, Canc & Inflammat Res, Odense, Denmark
[4] IRCCS Ist Tumori Giovanni Paolo II, Med Oncol Unit, Bari, Italy
[5] IRCCS Ist Tumori Giovanni Paolo II, Med Oncol Unit, IRCCS Bari, Bari, Italy
[6] Univ Bari, Dept Biomed Sci & Human Oncol DIMO, Bari, Italy
关键词
Cancer; Immune system; CD39; CD73; Immune checkpoints; CELLS PRODUCE ADENOSINE; T-CELLS; EXTRACELLULAR ADENOSINE; TUMOR-GROWTH; TH17; CELLS; B-CELLS; IMMUNOSUPPRESSIVE ACTIVITY; PROGNOSTIC BIOMARKER; PERIPHERAL TOLERANCE; CATALYTIC-PROPERTIES;
D O I
10.1016/j.lfs.2021.119826
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The immunosuppressive tumor microenvironment has been implicated in attenuating anti-tumoral immune responses and tumor growth in various cancers. Inhibitory immune checkpoints have been introduced as the primary culprits for developing the immunosuppressive tumor microenvironment. Therefore, a better understanding of the cross-talk between inhibitory immune checkpoints in the tumor microenvironment can pave the way for introducing novel approaches for treating affected patients. Growing evidence indicates that CD39 and CD73, as novel checkpoints, can transform adenosine triphosphate (ATP)-mediated pro-inflammatory tumor microenvironment into an adenosine-mediated immunosuppressive one via the purinergic signaling pathway. Indeed, enzymatic processes of CD39 and CD73 have crucial roles in adjusting the extent, intensity, and chemical properties of purinergic signals. This study aims to review the biological function of CD39 and CD73 and shed light on their significance in regulating anti-tumoral immune responses in various cancers.
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页数:10
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共 217 条
[1]   Ectonucleoside triphosphate diphosphohydrolase-1 (E-NTPDase1/CD39) as a new prognostic marker in chronic lymphocytic leukemia [J].
Abousamra, Nashwa Khairat ;
El-Din, Manal Salah ;
Elzahaf, Eman Hamza ;
Esmael, Mohammed Ebrahim .
LEUKEMIA & LYMPHOMA, 2015, 56 (01) :113-119
[2]  
Ahlmanner Filip, 2018, Oncotarget, V9, P36993, DOI 10.18632/oncotarget.26435
[3]   CD73 and adhesion of B-Cells to follicular dendritic cells [J].
Airas, L .
LEUKEMIA & LYMPHOMA, 1998, 29 (1-2) :37-+
[4]   CD73 mediates adhesion of B cells to follicular dendritic cells [J].
Airas, L ;
Jalkanen, S .
BLOOD, 1996, 88 (05) :1755-1764
[5]   CD73-Generated Adenosine: Orchestrating the Tumor-Stroma Interplay to Promote Cancer Growth [J].
Allard, Bertrand ;
Turcotte, Martin ;
Stagg, John .
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2012,
[6]   On the mechanism of anti-CD39 immune checkpoint therapy [J].
Allard, David ;
Allard, Bertrand ;
Stagg, John .
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2020, 8 (01)
[7]  
[Anonymous], 2021, CANCER DISCOV, V11
[8]   Penetrating Cations Enhance Uncoupling Activity of Anionic Protonophores in Mitochondria [J].
Antonenko, Yuri N. ;
Khailova, Ljudmila S. ;
Knorre, Dmitry A. ;
Markova, Olga V. ;
Rokitskaya, Tatyana I. ;
Ilyasova, Tatyana M. ;
Severina, Inna I. ;
Kotova, Elena A. ;
Karavaeva, Yulia E. ;
Prikhodko, Anastasia S. ;
Severin, Fedor F. ;
Skulachev, Vladimir P. .
PLOS ONE, 2013, 8 (04)
[9]   Anti-CD73 in Cancer Immunotherapy: Awakening New Opportunities [J].
Antonioli, Luca ;
Yegutkin, Gennady G. ;
Pacher, Pal ;
Blandizzi, Corrado ;
Hasko, Gyorgy .
TRENDS IN CANCER, 2016, 2 (02) :95-109
[10]   Immunity, inflammation and cancer: a leading role for adenosine [J].
Antonioli, Luca ;
Blandizzi, Corrado ;
Pacher, Pal ;
Hasko, Gyoergy .
NATURE REVIEWS CANCER, 2013, 13 (12) :842-857