Phosphoinositide 3-kinase signalling in lung disease: leucocytes and beyond

被引：50

作者：

Medina-Tato, David A. ^{[1
]}

Ward, Stephen G. ^{[1
]}

Watson, Malcolm L. ^{[1
]}

机构：

[1] Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England

来源：

IMMUNOLOGY | 2007年 / 121卷 / 04期

关键词：

PI3K; lung disease; asthma; inflammation;

D O I：

10.1111/j.1365-2567.2007.02663.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The family of lipid kinases termed phosphoinositide-3-kinase (PI3K) is known to contribute at multiple levels to innate and adaptive immune responses, and is hence an attractive target for drug discovery in inflammatory and autoimmune disease, including respiratory diseases. The development of isoform-selective pharmacological inhibitors, targeted gene manipulation and short interfering RNA (siRNA) target validation have facilitated a better understanding of the role that each member of this family of kinases plays in the physiology and pathology of the respiratory system. In this review, we will evaluate the evidence for the roles of specific PI3K isoforms in the lung and airways, and discuss their potential as targets for novel drug therapies.

引用

页码：448 / 461

页数：14

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