IL-17 and its role in inflammatory, autoimmune, and oncological skin diseases: state of art

被引：65
作者：
Bernardini, Nicoletta [1 ]
Skroza, Nevena [1 ]
Tolino, Ersilia [1 ]
Mambrin, Alessandra [1 ]
Anzalone, Alessia [1 ]
Balduzzi, Veronica [1 ]
Colapietra, Daniela [1 ]
Marchesiello, Anna [1 ]
Michelini, Simone [1 ]
Proietti, Ilaria [1 ]
Potenza, Concetta [1 ]
机构：
[1] Sapienza Univ Rome, Fiorini Hosp, Dept Med Surg Sci & Biotechnol, Dermatol Unit Daniele Innocenzi,Polo Pontino, Teracina, Italy
来源：
INTERNATIONAL JOURNAL OF DERMATOLOGY | 2020年 / 59卷 / 04期
关键词：
PROPIONIBACTERIUM-ACNES; TH17; CELLS; ATOPIC-DERMATITIS; ALOPECIA-AREATA; PSORIASIS; INTERLEUKIN-17; EXPRESSION; PATHWAY; IL-23; SERUM;
D O I：
10.1111/ijd.14695
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Recent data support the theory of the involvement of IL-17 in the pathogenesis of several chronic inflammatory skin diseases (psoriasis, atopic dermatitis, acne, hidradenitis suppurativa) and autoimmune skin diseases (alopecia areata, vitiligo, bullous diseases). Even if the role of IL-17 in inflammatory and autoimmune diseases has been reported extensively, its role in tumor is still controversial. Some reports show that Th17 cells eradicate tumors, while others reveal that they promote the initiation and early growth of tumors. Herein, we review the role of IL-17 in the involvement of some common dermatologic diseases: psoriasis, atopic dermatitis, hidradenitis suppurativa, acne, vitiligo, melanoma, and nonmelanoma skin cancers.
引用
收藏
页码：406 / 411
页数：6
相关论文
共 61 条
  • [1] Propionibacterium acnes Induces an IL-17 Response in Acne Vulgaris that Is Regulated by Vitamin A and Vitamin D
    Agak, George W.
    Qin, Min
    Nobe, Jennifer
    Kim, Myung-Hwa
    Krutzik, Stephan R.
    Tristan, Grogan R.
    Elashoff, David
    Garban, Hermes J.
    Kim, Jenny
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2014, 134 (02) : 366 - 373
  • [2] Mutual upregulation of endothelin-1 and IL-25 in atopic dermatitis
    Aktar, M. K.
    Kido-Nakahara, M.
    Furue, M.
    Nakahara, T.
    [J]. ALLERGY, 2015, 70 (07) : 846 - 854
  • [3] Targeting the IL-23/IL-17 axis for the treatment of psoriasis and psoriatic arthritis
    Alunno, Alessia
    Carubbi, Francesco
    Cafaro, Giacomo
    Pucci, Giacomo
    Battista, Francesca
    Bartoloni, Elena
    Giacomelli, Roberto
    Schillaci, Giuseppe
    Gerli, Roberto
    [J]. EXPERT OPINION ON BIOLOGICAL THERAPY, 2015, 15 (12) : 1727 - 1737
  • [4] IL-17 Signaling: The Yin and the Yang
    Amatya, Nilesh
    Garg, Abhishek V.
    Gaffen, Sarah L.
    [J]. TRENDS IN IMMUNOLOGY, 2017, 38 (05) : 310 - 322
  • [5] T-helper 17 cytokines (interleukins 17, 21, 22, and 6, and tumor necrosis factor-) in patients with alopecia areata: association with clinical type and severity
    Atwa, Mona A.
    Youssef, Nahed
    Bayoumy, Nervana M.
    [J]. INTERNATIONAL JOURNAL OF DERMATOLOGY, 2016, 55 (06) : 666 - 672
  • [6] Th17 cellsin cancer: the ultimate identity crisis
    Bailey, Stefanie R.
    Nelson, Michelle H.
    Himes, Richard A.
    Li, Zihai
    Mehrotra, Shikhar
    Paulos, Chrystal M.
    [J]. FRONTIERS IN IMMUNOLOGY, 2014, 5
  • [7] The role of helper and regulatory T cells in the pathogenesis of vitiligo
    Basak, Pinar Y.
    Adiloglu, Ali K.
    Ceyhan, Ali Murat
    Tas, Tekin
    Akkaya, Vahide B.
    [J]. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2009, 60 (02) : 256 - 260
  • [8] Role of interleukin-17 in the pathogenesis of vitiligo
    Bassiouny, D. A.
    Shaker, O.
    [J]. CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2011, 36 (03) : 292 - 297
  • [9] IL-17 in Chronic Inflammation: From Discovery to Targeting
    Beringer, Audrey
    Noack, Melissa
    Miossec, Pierre
    [J]. TRENDS IN MOLECULAR MEDICINE, 2016, 22 (03) : 230 - 241
  • [10] Systemic Inflammation and Cardiovascular Comorbidity in Psoriasis Patients: Causes and Consequences
    Boehncke, Wolf-Henning
    [J]. FRONTIERS IN IMMUNOLOGY, 2018, 9
1234567