IL-17 and its role in inflammatory, autoimmune, and oncological skin diseases: state of art

被引：72

作者：

Bernardini, Nicoletta ^{[1
]}

Skroza, Nevena ^{[1
]}

Tolino, Ersilia ^{[1
]}

Mambrin, Alessandra ^{[1
]}

Anzalone, Alessia ^{[1
]}

Balduzzi, Veronica ^{[1
]}

Colapietra, Daniela ^{[1
]}

Marchesiello, Anna ^{[1
]}

Michelini, Simone ^{[1
]}

Proietti, Ilaria ^{[1
]}

Potenza, Concetta ^{[1
]}

机构：

[1] Sapienza Univ Rome, Fiorini Hosp, Dept Med Surg Sci & Biotechnol, Dermatol Unit Daniele Innocenzi,Polo Pontino, Teracina, Italy

来源：

INTERNATIONAL JOURNAL OF DERMATOLOGY | 2020年 / 59卷 / 04期

关键词：

PROPIONIBACTERIUM-ACNES; TH17; CELLS; ATOPIC-DERMATITIS; ALOPECIA-AREATA; PSORIASIS; INTERLEUKIN-17; EXPRESSION; PATHWAY; IL-23; SERUM;

D O I：

10.1111/ijd.14695

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Recent data support the theory of the involvement of IL-17 in the pathogenesis of several chronic inflammatory skin diseases (psoriasis, atopic dermatitis, acne, hidradenitis suppurativa) and autoimmune skin diseases (alopecia areata, vitiligo, bullous diseases). Even if the role of IL-17 in inflammatory and autoimmune diseases has been reported extensively, its role in tumor is still controversial. Some reports show that Th17 cells eradicate tumors, while others reveal that they promote the initiation and early growth of tumors. Herein, we review the role of IL-17 in the involvement of some common dermatologic diseases: psoriasis, atopic dermatitis, hidradenitis suppurativa, acne, vitiligo, melanoma, and nonmelanoma skin cancers.

引用

页码：406 / 411

页数：6

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