Large volume donor plasmapheresis in inherited thrombophilia implicated in arterial thrombosis

被引：16

作者：

Ovali, E ^{[1
]}

Ratip, S

Özmenoglu, M

Karti, SS

Uçar, F

Ukinç, K

Yilmaz, M

Kosucu, P

机构：

[1] Karadeniz Tech Univ, Dept Hematol, Trabzon, Turkey

[2] Marmara Univ Hosp, Dept Hematol, Istanbul, Turkey

[3] Karadeniz Tech Univ, Dept Neurol, Trabzon, Turkey

[4] Karadeniz Tech Univ, Dept Radiol, Trabzon, Turkey

来源：

TRANSFUSION AND APHERESIS SCIENCE | 2003年 / 28卷 / 03期

关键词：

plasmapheresis; prothrombin; 2021OG-A; MTHFR; 677C-T; thrombosis;

D O I：

10.1016/S1473-0502(03)00054-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background. Life-threatening complications following apheresis are rare, and include venous thrombosis. Arterial thrombosis following apheresis has not been reported. Case report. A 48 year old donor had cerebral infarction following large volume plasma donation. The outcome was fatal. He was found to be heterozygous for both methylene tetrahydrofolate reductase (MTHFR) 677C-T mutation and Prothrombin 20210G-A allele. Conclusion. This case suggests that large volume plasma donation may trigger arterial thrombotic events in inherited thrombophilia. Therefore, the effects of plasmapheresis on coagulation system should be studied thoroughly. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：201 / 206

页数：6

共 35 条

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