Effects of Dietary Supplementation with Myo-inositol on Hepatic Expression of Glycolytic and Fructolytic Enzyme Genes in Rats Fed a High-sucrose Diet

被引：0

作者：

Hibi, Mayu ^{[1
]}

Sugiura, Sakura ^{[2
]}

Nakagawa, Tomoyuki ^{[1
,2
]}

Hayakawa, Takashi ^{[1
,2
]}

Shimada, Masaya ^{[1
,2
]}

机构：

[1] Gifu Univ, Grad Sch Nat Sci & Technol, Dept Life Sci & Chem, Div Life Sci Food, 1-1 Yanagido, Gifu 5011193, Japan

[2] Gifu Univ, Fac Appl Biol Sci, Dept Appl Life Sci, 1-1 Yanagido, Gifu 5011193, Japan

来源：

JOURNAL OF OLEO SCIENCE | 2021年 / 70卷 / 05期

关键词：

KHK; liver; myo-inositol; rats; sucrose; ELEMENT-BINDING PROTEIN; CHREBP; ACID;

D O I：

10.5650/jos.ess20340

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

We examined effects of a major lipotrope, myo-inositol, on the expression of primary glycolytic (glucokinase and phosphofructokinase) and fructolytic enzyme (ketohexokinase [KHK] and aldolase B) genes in the livers of rats fed a control diet, high-sucrose diet, or high-sucrose diet supplemented with 0.5% myo-inositol for 14 d. Supplementation with myo-inositol decreased the hepatic expression of fructolytic enzyme genes, but not that of glycolytic enzyme genes, and the levels of triglycerides, fatty acid synthase, and KHK proteins in high-sucrose diet-induced fatty liver. The study results suggest that myo-inositol represses primary fructlysis, but not glycolysis, in high-sucrose diet-induced fatty liver.

引用

页码：697 / 702

页数：6

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