Recent Advances of Metallocenes for Medicinal Chemistry

被引：40

作者：

Santos, Miguel M. ^{[1
]}

Bastos, Pedro ^{[1
]}

Catela, Isabelle ^{[1
]}

Zalewska, Karolina ^{[1
]}

Branco, Luis C. ^{[1
]}

机构：

[1] Univ Nova Lisboa, Fac Ciencias & Tecnol, Chem Dept, LAQV REQUIMTE, Campus FCT UNL,POB 2829-516, Lisbon, Portugal

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2017年 / 17卷 / 09期

关键词：

Anti-HIV; anti-malaria; anti-tumoral; ferrocene derivatives; medicinal chemistry; metallocenes; VITRO ANTICANCER ACTIVITY; IN-VITRO; STRUCTURAL-CHARACTERIZATION; CANCER-CELLS; OXOVANADIUM(IV) COMPLEXES; FERROCENYL DERIVATIVES; ANTIMALARIAL ACTIVITY; CYTOTOXIC ACTIVITY; RECOGNITION; LIGANDS;

D O I：

10.2174/1389557516666161031141620

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Background: The recent advances for the synthesis and application of different metallocenes for Medicinal Chemistry is reviewed. Objective: This manuscript presents the different metallocene scaffolds, with special emphasis on ferrocene derivatives, and their potential pharmaceutical application. Over the last years, the synthesis of new metallocene compounds and their biological and medicinal effects against some types of diseases (e. g. anti-tumoral, antibiotics, anti-viral) have been reported. From the medicinal point of view, the attractive properties of metallocene derivatives, such as their high stability, low toxicity and appealing redox behaviors are particularly relevant. Results: This area has attracted many researchers as well as the pharmaceutical industry due to the promising results of some metallocenes, in particular ferrocene compounds, in breast cancer and malaria.

引用

页码：771 / 784

页数：14

共 90 条

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