Cp*CoIII-Catalyzed C(7)-H Bond Annulation of Indolines with Alkynes

被引：23
|
作者：
Mandal, Rajib [1 ]
Garai, Bholanath [1 ]
Sundararaju, Basker [1 ]
机构：
[1] Indian Inst Technol Kanpur, Dept Chem, Fine Chem Lab, Kanpur 208016, Uttar Pradesh, India
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 86卷 / 14期
关键词：
N-CARBAMOYL INDOLINES; H AMIDATION; COBALT(III)-CATALYZED SYNTHESIS; CARBON-HYDROGEN; INDOLES; ARENES; FUNCTIONALIZATION; INTERMEDIATE; ALKENYLATION; DERIVATIVES;
D O I：
10.1021/acs.joc.1c00713
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient protocol for the synthesis of biologically essential pyrroloquinolinones has been developed under Cp*Co-III in catalysis, which involves a cascade reaction of C(7)-H alkenylation with alkynes followed by nucleophilic addition. A wide variety of internal alkynes including enyne, diyne, and ynamide and more challenging terminal alkynes were successfully employed for the annulation in good to excellent yield with high regioselectivity.
引用
收藏
页码：9407 / 9417
页数：11
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