The R(-)-enantiomer of efonidipine blocks T-type but not L-type calcium current in guinea pig ventricular myocardium

被引：29
|
作者：
Tanaka, H [1 ]
Komikado, C
Shimada, H
Takeda, K
Namekata, I
Kawanishi, T
Shigenobu, K
机构：
[1] Toho Univ, Sch Pharmaceut Sci, Dept Pharmacol, Chiba 2748510, Japan
[2] Natl Inst Hlth Sci, Div Biol Chem & Biol, Tokyo 1588501, Japan
来源：
JOURNAL OF PHARMACOLOGICAL SCIENCES | 2004年 / 96卷 / 04期
关键词：
R(-)-efonidipine; T-type Ca2+ channel; cardiomyocyte;
D O I：
10.1254/jphs.RCJ04001X
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In guinea pig ventricular cardiomyocytes, the R(-)-enantiomer of efonidipine concentration-dependently blocked T-type Ca2+ current with 85% inhibition at 1 muM. In contrast, R(-)-efonidipine (1 muM) had no effect on the L-type Ca2+ current and Ca2+ transient in cardiomyocytes and contractile force in papillary muscles. Thus, R(-)-efonidipine is a highly selective blocker of the T-type Ca2+ current in native myocardia.
引用
收藏
页码：499 / 501
页数：3
相关论文
共 50 条
  • [1] The R(-)-enantiomer of efonidipine blocks T-type but not L-type calcium current in guinea-pig ventricular myocardium
    Komikado, C
    Shimada, H
    Takeda, K
    Namekata, I
    Kawanisi, T
    Tanaka, H
    Shigenobu, K
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005, 97 : 234P - 234P
  • [2] L-type and T-type Ca2+ current in cultured ventricular myocytes of guinea pig
    Zorn-Pauly, K
    Schaffer, P
    Pelzmann, B
    Bernhart, E
    Lang, P
    Koidl, B
    BIOPHYSICAL JOURNAL, 2001, 80 (01) : 636A - 637A
  • [3] L-type and T-type Ca2+ current in cultured ventricular guinea pig myocytes
    Zorn-Pauly, K
    Schaffer, P
    Pelzmann, B
    Bernhart, E
    Lang, P
    Koidl, B
    PHYSIOLOGICAL RESEARCH, 2004, 53 (04) : 369 - 377
  • [4] Effect of dipfluzine on L-type calcium current in guinea pig ventricular myocytes
    Zhang, YJ
    Li, DP
    Xue, BJ
    Wang, YL
    He, RR
    ACTA PHARMACOLOGICA SINICA, 2001, 22 (08): : 701 - 705
  • [5] Inhibition of the T-type and L-type calcium currents by halothane in guinea pig atrial myocytes.
    Stadnicka, A
    Kwok, WM
    Kampine, JP
    Bosnjak, ZJ
    ANESTHESIOLOGY, 1996, 85 (3A) : A622 - A622
  • [6] SLOW INACTIVATION OF L-TYPE CALCIUM CURRENT DISTORTS THE MEASUREMENT OF L-TYPE AND T-TYPE CALCIUM CURRENT IN PURKINJE MYOCYTES
    DATYNER, NB
    COHEN, IS
    JOURNAL OF GENERAL PHYSIOLOGY, 1993, 102 (05): : 859 - 869
  • [7] Propofol inhibits cardiac L-type calcium current in guinea pig ventricular myocytes
    Yang, CY
    Wong, CS
    Yu, CC
    Luk, HN
    Lin, CI
    ANESTHESIOLOGY, 1996, 84 (03) : 626 - 635
  • [8] Modulation of L-type calcium current by internal potassium in guinea pig ventricular myocytes
    Linz, KW
    Meyer, R
    CARDIOVASCULAR RESEARCH, 1997, 33 (01) : 110 - 122
  • [9] STIMULATORY EFFECT OF OUABAIN ON T-TYPE AND L-TYPE CALCIUM CURRENTS IN GUINEA-PIG CARDIAC MYOCYTES
    LEGRAND, B
    DEROUBAIX, E
    COULOMBE, A
    CORABOEUF, E
    AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 258 (05): : H1620 - H1623
  • [10] The dihydropyridine analogue cerebrocrast blocks both T-type and L-type calcium currents
    Drigelova, Maria
    Tarabova, Bohumila
    Duburs, Gunars
    Lacinova, Lubica
    CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2009, 87 (11) : 923 - 932
12345