Daily rhythms of the expression of genes from the somatotropic axis: The influence on tilapia (Oreochromis niloticus) of feeding and growth hormone administration at different times

被引:31
作者
Costa, Leandro S. [1 ,2 ]
Rosa, Priscila V. [1 ]
Fortes-Silva, Rodrigo [3 ]
Javier Sanchez-Vazquez, F. [2 ]
Lopez-Olmeda, Jose F. [2 ]
机构
[1] Univ Fed Lavras, Dept Anim Sci, BR-37200000 Lavras, MG, Brazil
[2] Univ Murcia, Fac Biol, Dept Physiol, Reg Campus Int Excellence,Campus Mare Nostrum, E-30100 Murcia, Spain
[3] Univ Bahia, Agr Sci Biol & Environm Ctr, BR-44380000 Cruz De Almas, Bahia, Brazil
来源
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY | 2016年 / 181卷
关键词
Pituitary adenylate cyclase-activating polypeptide; Growth hormone; Insulin-like growth factor; Growth hormone receptor; IGF receptor; GH chronopharmacology; Teleost fish; FACTOR MESSENGER-RNA; IGF-II GENE; SKELETAL-MUSCLE; CHUM SALMON; GRASS CARP; INSULIN; GH; TELEOST; FISH; RECEPTOR;
D O I
10.1016/j.cbpc.2015.12.008
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The aim of this research was to investigate the presence of daily rhythms in the somatotropic axis of tilapia fed at two times (mid-light, ML or mid-dark, MD) and the influence of the time of day of growth hormone (GH) administration on the response of this axis. Two different GH injection times were tested: ZT 3 (3 h after lights on) and ZT 15 (3 h after lights off). In both experiments, the mRNA expression levels of hypothalamic pituitary adenylate cyclase-activating polypeptide (pacap), pituitary growth hormone (gh), liver insulin-like growth factors (igf1 and igf2a), and liver and muscle growth hormone receptors (ghr1 and ghr2) and IGF receptors (igf1ra and igf2r) were evaluated by means of qPCR. Daily rhythms were observed in the liver for ghr1, ghr2 and igf1r but only in fish fed at ML, with the acrophases located in the light phase (ZT 3:30, 3:31 and 7:38 h, respectively). In the muscle, ghr1 displayed a significant rhythm in both groups and ghr2 in ML fed fish (acrophases at ZT 5:29, 7:14 and 9:23 h). The time of both GH administration and feeding influenced the response to GH injection: ML fed fish injected with GH at ZT 15 h showed a significant increase in liver igfl, igf1a and ghr2; and muscle ghr2 expression. This is the first report that describes the existence of daily rhythms in the somatotropic axis of tilapia and its time dependent responses of GH administration. Our results should be considered when investigating the elements of the somatotropic axis in tilapia and GH administration. (C) 2015 Published by Elsevier Inc.
引用
收藏
页码:27 / 34
页数:8
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