19F PARASHIFT Probes for Magnetic Resonance Detection of H2O2 and Peroxidase Activity

被引：64

作者：

Yu, Meng ^{[1
]}

Bouley, Bailey S. ^{[1
]}

Xie, Da ^{[1
]}

Enriquez, Jose S. ^{[1
]}

Que, Emily L. ^{[1
]}

机构：

[1] Univ Texas Austin, Dept Chem, Austin, TX 78712 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2018年 / 140卷 / 33期

关键词：

RESPONSIVE MRI CONTRAST; COBALT(II) COMPLEX; CELL TRACKING; AGENTS; REDOX; NANOEMULSIONS; MYELOPEROXIDASE; TEMPERATURE; HYPOXIA; WATER;

D O I：

10.1021/jacs.8b05685

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Elevated levels of reactive oxygen species and peroxidase expression are often associated with inflammation and inflammatory diseases. We developed two novel Co(II) complexes that can be used to detect oxidative activity associated with inflammation using F-19 magnetic resonance imaging (MRI). These agents display a large change in F-19 chemical shift upon oxidation from Co(II) to Co(III), facilitating selective visualization of both species using chemical shift selective pulse sequences. This large chemical shift change is attributed to a large magnetic anisotropy in the high spin Co(II) complexes. Importantly, the differing reactivity of the two agents allows for detection of either H2O2 production and/or the activity of peroxidase enzymes, providing two useful platforms for F-19 MR hot spot imaging of oxidative events associated with biological inflammation.

引用

页码：10546 / 10552

页数：7

共 47 条

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