Glutamate Receptor Biology and its Clinical Significance in Neuropsychiatric Systemic Lupus Erythematosus

被引：36

作者：

Aranow, Cynthia ^{[1
]}

Diamond, Betty ^{[1
]}

Mackay, Meggan ^{[1
]}

机构：

[1] Feinstein Inst Med Res, Manhasset, NY 11030 USA

来源：

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2010年 / 36卷 / 01期

关键词：

Neuropsychiatric SLE; Cognitive impairment; Emotional impairment; NMDAR; Anti-NR2; antibody; METHYL-D-ASPARTATE; CENTRAL-NERVOUS-SYSTEM; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; EXCITATORY AMINO-ACIDS; P-PROTEIN ANTIBODIES; CEREBROSPINAL-FLUID; COGNITIVE DYSFUNCTION; ANTIPHOSPHOLIPID ANTIBODIES; SYNAPTIC TRANSMISSION; RHEUMATIC-DISEASES;

D O I：

10.1016/j.rdc.2009.12.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The recent appreciation that a subset of anti-DNA antibodies cross-reacts with the N-methyl-d-aspartate receptor encourages a renewed examination of antibrain reactivity in systemic lupus erythematosus (SLE) autoantibodies. Moreover, investigations of their autospecificity present a paradigm for studies of antibrain reactivity and show that (1) serum antibodies access brain tissue only after a compromise of blood-brain barrier integrity, (2) the same antibodies have differential effects on brain function depending on the region of brain exposed to the antibodies, and (3) insults to the blood-brain barrier are regional rather than diffuse. These studies suggest that an anatomic classification scheme for neuropsychiatric SLE may facilitate research on etiopathogenesis and the design of clinical trials.

引用

页码：187 / +

页数：17

共 83 条

[1] The prevalence of neuropsychiatric syndromes in systemic lupus erythematosus [J].