Age- and sex-related features of atherosclerosis from coronary computed tomography angiography in patients prior to acute coronary syndrome: results fromthe ICONIC study

被引：28

作者：

Conte, Edoardo ^{[1
]}

Dwivedi, Aeshita ^{[2
,3
]}

Mushtaq, Saima ^{[1
]}

Pontone, Gianluca ^{[1
]}

Lin, Fay Y. ^{[2
,3
]}

Hollenberg, Emma J. ^{[2
,3
]}

Lee, Sang-Eun ^{[4
,5
]}

Bax, Jeroen ^{[6
]}

Cademartiri, Filippo ^{[7
]}

Chinnaiyan, Kavitha ^{[8
]}

Chow, Benjamin J. W. ^{[9
]}

Cury, Ricardo C. ^{[10
]}

Feuchtner, Gudrun ^{[11
]}

Hadamitzky, Martin ^{[12
]}

Kim, Yong-Jin ^{[13
]}

Baggiano, Andrea ^{[1
]}

Leipsic, Jonathon ^{[14
]}

Maffei, Erica ^{[15
]}

Marques, Hugo ^{[16
]}

Plank, Fabian ^{[11
]}

Raff, Gilbert L. ^{[8
]}

van Rosendael, Alexander R. ^{[2
,3
,6
]}

Villines, Todd C. ^{[17
]}

Weirich, Harald G. ^{[11
]}

Al'Aref, Subhi J. ^{[2
,3
]}

Baskaran, Lohendran ^{[2
,3
,18
]}

Cho, Iksung ^{[2
,3
,19
,20
]}

Danad, Ibrahim ^{[21
]}

Han, Donghee ^{[19
]}

Heo, Ran ^{[22
]}

Lee, Ji Hyun ^{[2
,3
,19
,22
]}

Stuijfzand, Wijnand J. ^{[2
,3
]}

Gransar, Heidi ^{[23
]}

Lu, Yao ^{[2
,3
]}

Sung, Ji Min ^{[19
]}

Park, Hyung-Bok ^{[19
]}

Al-Mallah, Mouaz H. ^{[24
]}

Goncalves, Pedro de Araujo ^{[25
]}

Berman, Daniel S. ^{[23
]}

Budoff, Matthew J. ^{[26
]}

Samady, Habib ^{[27
]}

Shaw, Leslee J. ^{[2
,3
]}

Stone, Peter H. ^{[28
]}

Virmani, Renu ^{[29
]}

Narula, Jagat ^{[30
,31
]}

Min, James K. ^{[2
,3
]}

Chang, Hyuk-Jae ^{[19
]}

Andreini, Daniele ^{[1
]}

机构：

[1] Univ Milan, Ctr Cardiol Monzino, Dept Clin Sci & Community Hlth, IRCCS, Via C Parea 4, I-20138 Milan, Italy

[2] New York Presbyterian Hosp, Dalio Inst Cardiovasc Imaging, Dept Radiol, New York, NY USA

[3] Weill Cornell Med, New York, NY USA

[4] Ewha Womans Univ, Dept Internal Med, Div Cardiol, Seoul Hosp, Seoul, South Korea

[5] Yonsei Univ, Yonsei Univ Hlth Syst, Yonsei Cedars Sinai Integrat Cardiovasc Imaging R, Dept Cardiovasc Imaging,Coll Med, Seoul, South Korea

[6] Leiden Univ, Dept Cardiol, Med Ctr, Leiden, Netherlands

[7] SDN IRCCS, Dept Cardiovasc Imaging, Cardiovasc Imaging Ctr, Naples, Italy

[8] William Beaumont Hosp, Dept Cardiol, Royal Oak, MI USA

[9] Univ Ottawa, Dept Med & Radiol, Ottawa, ON, Canada

[10] Miami Cardiac & Vasc Inst, Dept Radiol, Miami, FL USA

[11] Med Univ Innsbruck, Dept Radiol, Innsbruck, Austria

[12] German Heart Ctr Munich, Dept Radiol & Nucl Med, Munich, Germany

[13] Seoul Natl Univ, Seoul Natl Univ Hosp, Cardiovasc Ctr, Dept Internal Med,Coll Med, Seoul, South Korea

[14] Univ British Columbia, Dept Med & Radiol, Vancouver, BC, Canada

[15] ASUR, Area Vasta 1, Dept Radiol, Urbino, Italy

[16] Hosp Luz, Unit Cardiovasc Imaging, UNICA, Lisbon, Portugal

[17] Univ Virginia Hlth Syst, Dept Med, Charlottesville, VA USA

[18] Natl Heart Ctr, Dept Cardiovasc Med, Singapore, Singapore

[19] Yonsei Univ, Severance Cardiovasc Hosp, Integrat Cardiovasc Imaging Res Ctr, Div Cardiol,Coll Med, Seoul, South Korea

[20] Chung Ang Univ Hosp, Dept Cardiol, Seoul, South Korea

[21] Vrije Univ Amsterdam, Dept Cardiol, Med Ctr, Amsterdam, Netherlands

[22] Hangyang Univ, Dept Internal Med, Div Cardiol, Med Ctr, Seoul, South Korea

[23] Cedars Sinai Med Ctr, Dept Imaging & Med, Los Angeles, CA 90048 USA

[24] Houston Methodist Hosp, Houston Methodist DeBakey Heart & Vasc Ctr, Dept Cardiovasc Med, Houston, TX USA

[25] Hosp Luz, Dept Cardiol, Unit Cardiovasc Imaging, UNICA, Lisbon, Portugal

[26] Los Angeles Biomed Res Inst, Dept Med, Torrance, CA USA

[27] Emory Univ, Sch Med, Div Cardiol, Atlanta, GA 30322 USA

[28] Brigham & Womens Hosp, Div Cardiovasc Med, Boston, MA USA

[29] CVPath Inst, Dept Pathol, Gaithersburg, MD USA

[30] Icahn Sch Med Mt Sinai, Mt Sinai Heart Zena & Michael A Wiener Cardiovasc, New York, NY 10029 USA

[31] Icahn Sch Med Mt Sinai, Marie Josee & Henry R Kravis Ctr Cardiovasc Hlth, New York, NY 10029 USA

来源：

EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING | 2021年 / 22卷 / 01期

基金：

新加坡国家研究基金会; 美国国家卫生研究院;

关键词：

atherosclerosis; gender medicine; cardiac CT; high-risk plaque features; CCTA; ARTERY-DISEASE; GENDER-DIFFERENCES; CT ANGIOGRAPHY; QUANTIFICATION; RISK;

D O I：

10.1093/ehjci/jeaa210

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims Although there is increasing evidence supporting coronary atherosclerosis evaluation by coronary computed tomography angiography (CCTA), no data are available on age and sex differences for quantitative plaque features. The aim of this study was to investigate sex and age differences in both qualitative and quantitative atherosclerotic features from CCTA prior to acute coronary syndrome (ACS). Methods and results Within the ICONIC study, in which 234 patients with subsequent ACS were propensity matched 1:1 with 234 non-event controls, our current subanalysis included only the ACS cases. Both qualitative and quantitative advance plaque analysis by CCTA were performed by a core laboratory. In 129 cases, culprit lesions identified by invasive coronary angiography at the time of ACS were co-registered to baseline CCTA precursor lesions. The study population was then divided into subgroups according to sex and age (<65 vs. = 65 years old) for analysis. Older patients had higher total plaque volume than younger patients. Within specific subtypes of plaque volume, however, only calcified plaque volume was higher in older patients (135.9 +/- 163.7 vs. 63.8 +/- 94.2 mm(3), P < 0.0001, respectively). Although no sex-related differences were recorded for calcified plaque volume, females had lower fibrous and fibrofatty plaque volume than males (Fibrofatty volume 29.6 +/- 44.1 vs. 75.3 +/- 98.6 mm(3), P = 0.0001, respectively). No sex-related differences in the prevalence of qualitative high-risk plaque features were found, even after separate analyses considering age were performed. Conclusion Our data underline the importance of age- and sex-related differences in coronary atherosclerosis presentation, which should be considered during CCTA-based atherosclerosis quantification.

引用

页码：24 / 33

页数：10

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