Monocyte to high-density lipoprotein cholesterol ratio predicts adverse cardiac events in patients with hypertrophic cardiomyopathy

被引：21

作者：

Ekizler, Firdevs Aysenur ^{[1
]}

Cay, Serkan ^{[1
]}

Acar, Burak ^{[2
]}

Tak, Bahar Tekin ^{[1
]}

Kafes, Habibe ^{[1
]}

Ozeke, Ozcan ^{[1
]}

Cetin, Elif Hande Ozcan ^{[1
]}

Ozcan, Firat ^{[1
]}

Topaloglu, Serkan ^{[1
]}

Tufekcioglu, Omac ^{[1
]}

Aras, Dursun ^{[1
]}

机构：

[1] Univ Hlth Sci, Yuksek Ihtisas Heart Educ & Res Hosp, Dept Cardiol, TR-06110 Ankara, Turkey

[2] Kocaeli Univ, Fac Med, Dept Cardiol, TR-41060 Kocaeli, Turkey

来源：

BIOMARKERS IN MEDICINE | 2019年 / 13卷 / 14期

关键词：

adverse outcomes; arrhythmia; cardiovascular death; hypertrophic cardiomyopathy; inflammation; monocyte to HDL cholesterol ratio; prognosis; risk stratification; MYOCARDIAL FIBROSIS; TASK-FORCE; INFLAMMATION; RISK; ASSOCIATION; MEDIATORS; CYTOKINES; DIAGNOSIS; DEATH; HEART;

D O I：

10.2217/bmm-2019-0089

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: The aim of the study was to investigate the monocyte count to HDL cholesterol ratio (MHR) on the prognosis of patients with hypertrophic cardiomyopathy (HCM). Materials & methods: A total of 411 patients with HCM were assessed. The primary end point was cardiovascular death or malignant arrhythmic events. Results: During the follow-up, primary end point was developed in 54 (13.1%) patients. Receiver operating characteristic (ROC) analysis showed that using a cut-off level of 14.57, MHR predicted the occurrence of primary end point with a sensitivity of 72% and specificity of 72%. In the multivariate model, high MHR was the only significant predictor of the primary end point. Conclusion: This study showed that higher MHR level is an independent predictor of malignant arrhythmia and death in patients with HCM.

引用

页码：1175 / 1186

页数：12

共 39 条

[31] A novel clinical risk prediction model for sudden cardiac death in hypertrophic cardiomyopathy (HCM Risk-SCD) [J].

O'Mahony, Constantinos ;

Jichi, Fatima ;

Pavlou, Menelaos ;

Monserrat, Lorenzo ;

Anastasakis, Aristides ;

Rapezzi, Claudio ;

Biagini, Elena ;

Ramon Gimeno, Juan ;

Limongelli, Giuseppe ;

McKenna, William J. ;

Omar, Rumana Z. ;

Elliott, Perry M. .

EUROPEAN HEART JOURNAL, 2014, 35 (30) :2010-+

[32]

Phadke R S, 2001, J Postgrad Med, V47, P165

[33] Assessment of monocyte to high density lipoprotein cholesterol ratio and lymphocyte-to-monocyte ratio in patients with metabolic syndrome [J].

Vahit, Demir ;

Akboga, Mehmet Kadri ;

Samet, Yilmaz ;

Huseyin, Ede .

BIOMARKERS IN MEDICINE, 2017, 11 (07) :535-540

[34] Hypertrophic cardiomyopathy: the interrelation of disarray, fibrosis, and small vessel disease [J].

Varnava, AM ;

Elliott, PM ;

Sharma, S ;

McKenna, WJ ;

Davies, MJ .

HEART, 2000, 84 (05) :476-482

[35] Usefulness of the monocyte-to-high-density lipoprotein cholesterol ratio to predict bare metal stent restenosis [J].

Yilmaz, Samet ;

Akboga, Mehmet K. ;

Sen, Fatih ;

Balci, Kevser G. ;

Aras, Dursun ;

Temizhan, Ahmet ;

Aydogdu, Sinan .

BIOMARKERS IN MEDICINE, 2016, 10 (09) :959-966

[36] ATP-Binding Cassette Transporters and HDL Suppress Hematopoietic Stem Cell Proliferation [J].

Yvan-Charvet, Laurent ;

Pagler, Tamara ;

Gautier, Emmanuel L. ;

Avagyan, Serine ;

Siry, Read L. ;

Han, Seongah ;

Welch, Carrie L. ;

Wang, Nan ;

Randolph, Gwendalyn J. ;

Snoeck, Hans W. ;

Tall, Alan R. .

SCIENCE, 2010, 328 (5986) :1689-1693

[37] Analysis of circulating apoptosis mediators and proinflammatory cytokines in patients with idiopathic hypertrophic cardiomyopathy - Comparison between nonobstructive and dilated-phase hypertrophic cardiomyopathy [J].

Zen, K ;

Irie, H ;

Doue, T ;

Takamiya, M ;

Yamano, T ;

Sawada, T ;

Azuma, A ;

Matsubara, H .

INTERNATIONAL HEART JOURNAL, 2005, 46 (02) :231-244

[38] C-Reactive Protein Promotes Cardiac Fibrosis and Inflammation in Angiotensin II-Induced Hypertensive Cardiac Disease [J].

Zhang, Rongxin ;

Zhang, Yuan Yuan ;

Huang, Xiao R. ;

Wu, Yin ;

Chung, Arthur C. K. ;

Wu, Ed Xuekui ;

Szalai, Alexander J. ;

Wong, Benjamin C. Y. ;

Lau, Chu-Pak ;

Lan, Hui Y. .

HYPERTENSION, 2010, 55 (04) :953-U265

[39] Prognostic Significance of Plasma High-Sensitivity C-Reactive Protein in Patients With Hypertrophic Cardiomyopathy [J].

Zhu, Ling ;

Zou, Yubao ;

Wang, Yilu ;

Luo, Xiaoliang ;

Sun, Kai ;

Wang, Hu ;

Jia, Lei ;

Liu, Yan ;

Zou, Juan ;

Yuan, Zuyi ;

Hui, Rutai ;

Kang, Lianming ;

Song, Lei ;

Wang, Jizheng .

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2017, 6 (02)

← 1 2 3 4 →