Monocyte to high-density lipoprotein cholesterol ratio predicts adverse cardiac events in patients with hypertrophic cardiomyopathy

被引：21

作者：

Ekizler, Firdevs Aysenur ^{[1
]}

Cay, Serkan ^{[1
]}

Acar, Burak ^{[2
]}

Tak, Bahar Tekin ^{[1
]}

Kafes, Habibe ^{[1
]}

Ozeke, Ozcan ^{[1
]}

Cetin, Elif Hande Ozcan ^{[1
]}

Ozcan, Firat ^{[1
]}

Topaloglu, Serkan ^{[1
]}

Tufekcioglu, Omac ^{[1
]}

Aras, Dursun ^{[1
]}

机构：

[1] Univ Hlth Sci, Yuksek Ihtisas Heart Educ & Res Hosp, Dept Cardiol, TR-06110 Ankara, Turkey

[2] Kocaeli Univ, Fac Med, Dept Cardiol, TR-41060 Kocaeli, Turkey

来源：

BIOMARKERS IN MEDICINE | 2019年 / 13卷 / 14期

关键词：

adverse outcomes; arrhythmia; cardiovascular death; hypertrophic cardiomyopathy; inflammation; monocyte to HDL cholesterol ratio; prognosis; risk stratification; MYOCARDIAL FIBROSIS; TASK-FORCE; INFLAMMATION; RISK; ASSOCIATION; MEDIATORS; CYTOKINES; DIAGNOSIS; DEATH; HEART;

D O I：

10.2217/bmm-2019-0089

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: The aim of the study was to investigate the monocyte count to HDL cholesterol ratio (MHR) on the prognosis of patients with hypertrophic cardiomyopathy (HCM). Materials & methods: A total of 411 patients with HCM were assessed. The primary end point was cardiovascular death or malignant arrhythmic events. Results: During the follow-up, primary end point was developed in 54 (13.1%) patients. Receiver operating characteristic (ROC) analysis showed that using a cut-off level of 14.57, MHR predicted the occurrence of primary end point with a sensitivity of 72% and specificity of 72%. In the multivariate model, high MHR was the only significant predictor of the primary end point. Conclusion: This study showed that higher MHR level is an independent predictor of malignant arrhythmia and death in patients with HCM.

引用

页码：1175 / 1186

页数：12

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