Ethnic and Racial Differences in Patients With Ewing Sarcoma
被引:83
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作者:
Worch, Jennifer
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机构:
Univ Calif San Francisco, Dept Pediat, Sch Med, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Pediat, Sch Med, San Francisco, CA 94143 USA
Worch, Jennifer
[1
]
Matthay, Katherine K.
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h-index: 0
机构:
Univ Calif San Francisco, Dept Pediat, Sch Med, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Pediat, Sch Med, San Francisco, CA 94143 USA
Matthay, Katherine K.
[1
]
Neuhaus, John
论文数: 0引用数: 0
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机构:
Univ Calif San Francisco, Dept Epidemiol Biostat, Sch Med, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Pediat, Sch Med, San Francisco, CA 94143 USA
Neuhaus, John
[2
]
Goldsby, Robert
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h-index: 0
机构:
Univ Calif San Francisco, Dept Pediat, Sch Med, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Pediat, Sch Med, San Francisco, CA 94143 USA
Goldsby, Robert
[1
]
DuBois, Steven G.
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h-index: 0
机构:
Univ Calif San Francisco, Dept Pediat, Sch Med, San Francisco, CA 94143 USAUniv Calif San Francisco, Dept Pediat, Sch Med, San Francisco, CA 94143 USA
DuBois, Steven G.
[1
]
机构:
[1] Univ Calif San Francisco, Dept Pediat, Sch Med, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Epidemiol Biostat, Sch Med, San Francisco, CA 94143 USA
Ewing sarcoma family of tumors;
prognosis;
soft tissue;
race;
ethnicity;
Surveillance Epidemiology and End Results;
ACUTE LYMPHOBLASTIC-LEUKEMIA;
PROGNOSTIC-FACTORS;
BONE;
CHILDHOOD;
CANCER;
SURVIVAL;
CHILDREN;
TUMORS;
RACE;
US;
D O I:
10.1002/cncr.24865
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
BACKGROUND: Ewing sarcoma (ES) was a malignant tumor of bone or soft tissue. One of the few risk factors for developing ES is race, with a higher incidence noted in populations of European rather than African or Asian ancestry. The goal of the current study was to evaluate racial and ethnic differences in presentation and overall survival (OS) among patients diagnosed with ES before age 40 years. METHODS: Data from the Surveillance, Epidemiology, and End Results database identified 1715 patients aged <40 years who were diagnosed with ES between 1973 and 2005. Racial and ethnic group differences were compared using chi-square tests. OS was estimated by Kaplan-Meier analysis and compared using log-rank tests and Cox models. RESULTS: Black patients had significantly more soft-tissue tumors compared with white non-Hispanic patients (P<0001). Asian and white Hispanic patients were found to have an intermediate frequency of soft-tissue tumors that also differed from white non-Hispanic patients (P<.0001). White Hispanic patients presented with a higher proportion of larger tumors compared with white non-Hispanic patients (P = .042). Black patients tended to be older than white non-Hispanic patients (P = .012). Sex, frequency of pelvic tumors, and metastatic status did not appear to differ by ethnicity or race. OS was found to differ according to race and ethnicity. Even after controlling for known confounders, OS was significantly worse for black, Asian, and white Hispanic patients compared with white non-Hispanic patients (P = .0031, P = .0182, and P = .0051, respectively). CONCLUSIONS: Ethnic and racial differences in characteristics and outcomes of patients with ES do exist. Understanding the etiology of these differences will require further study. Cancer 2010;116:983-8. (C) 2010 American Cancer Society.
机构:
Univ Calif San Francisco, Sch Med, Dept Pediat, San Francisco, CA 94143 USAUniv Calif San Francisco, Sch Med, Dept Pediat, San Francisco, CA 94143 USA
Worch, Jennifer
Matthay, Katherine
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Sch Med, Dept Pediat, San Francisco, CA 94143 USAUniv Calif San Francisco, Sch Med, Dept Pediat, San Francisco, CA 94143 USA
Matthay, Katherine
Goldsby, Robert
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Sch Med, Dept Pediat, San Francisco, CA 94143 USAUniv Calif San Francisco, Sch Med, Dept Pediat, San Francisco, CA 94143 USA
Goldsby, Robert
DuBois, Steven
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Sch Med, Dept Pediat, San Francisco, CA 94143 USAUniv Calif San Francisco, Sch Med, Dept Pediat, San Francisco, CA 94143 USA
机构:
NorthShore Univ HealthSyst, Dept Pediat, 1001 Univ Pl,Suite 348, Evanston, IL 60201 USA
Res Inst, 1001 Univ Pl,Suite 348, Evanston, IL 60201 USANorthShore Univ HealthSyst, Dept Pediat, 1001 Univ Pl,Suite 348, Evanston, IL 60201 USA
McKinney, Chelsea O.
Hahn-Holbrook, Jennifer
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h-index: 0
机构:
Chapman Univ, Crean Coll Hlth & Behav Sci, Orange, CA USANorthShore Univ HealthSyst, Dept Pediat, 1001 Univ Pl,Suite 348, Evanston, IL 60201 USA
Hahn-Holbrook, Jennifer
Chase-Lansdale, P. Lindsay
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Inst Policy Res, Evanston, IL USANorthShore Univ HealthSyst, Dept Pediat, 1001 Univ Pl,Suite 348, Evanston, IL 60201 USA
Chase-Lansdale, P. Lindsay
Ramey, Sharon L.
论文数: 0引用数: 0
h-index: 0
机构:
Virginia Tech, Caril Res Inst, Roanoke, VA USANorthShore Univ HealthSyst, Dept Pediat, 1001 Univ Pl,Suite 348, Evanston, IL 60201 USA
Ramey, Sharon L.
Krohn, Julie
论文数: 0引用数: 0
h-index: 0
机构:
Lake Cty Hlth Dept, Waukegan, IL USA
Ctr Community Hlth, Waukegan, IL USANorthShore Univ HealthSyst, Dept Pediat, 1001 Univ Pl,Suite 348, Evanston, IL 60201 USA
Krohn, Julie
Reed-Vance, Maxine
论文数: 0引用数: 0
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机构:
Baltimore Hlth Start Inc, Baltimore, MD USANorthShore Univ HealthSyst, Dept Pediat, 1001 Univ Pl,Suite 348, Evanston, IL 60201 USA
机构:
Univ Mississippi, Med Ctr, Div Gen Internal Med Hypertens, Dept Med, Jackson, MS 39216 USAUniv Mississippi, Med Ctr, Div Gen Internal Med Hypertens, Dept Med, Jackson, MS 39216 USA
Minor, Deborah S.
Wofford, Marion R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Mississippi, Med Ctr, Div Gen Internal Med Hypertens, Dept Med, Jackson, MS 39216 USAUniv Mississippi, Med Ctr, Div Gen Internal Med Hypertens, Dept Med, Jackson, MS 39216 USA
Wofford, Marion R.
Jones, Daniel W.
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机构:
Univ Mississippi, Med Ctr, Div Gen Internal Med Hypertens, Dept Med, Jackson, MS 39216 USAUniv Mississippi, Med Ctr, Div Gen Internal Med Hypertens, Dept Med, Jackson, MS 39216 USA