Ethnic and Racial Differences in Patients With Ewing Sarcoma

被引:83
|
作者
Worch, Jennifer [1 ]
Matthay, Katherine K. [1 ]
Neuhaus, John [2 ]
Goldsby, Robert [1 ]
DuBois, Steven G. [1 ]
机构
[1] Univ Calif San Francisco, Dept Pediat, Sch Med, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Epidemiol Biostat, Sch Med, San Francisco, CA 94143 USA
基金
美国国家卫生研究院;
关键词
Ewing sarcoma family of tumors; prognosis; soft tissue; race; ethnicity; Surveillance Epidemiology and End Results; ACUTE LYMPHOBLASTIC-LEUKEMIA; PROGNOSTIC-FACTORS; BONE; CHILDHOOD; CANCER; SURVIVAL; CHILDREN; TUMORS; RACE; US;
D O I
10.1002/cncr.24865
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BACKGROUND: Ewing sarcoma (ES) was a malignant tumor of bone or soft tissue. One of the few risk factors for developing ES is race, with a higher incidence noted in populations of European rather than African or Asian ancestry. The goal of the current study was to evaluate racial and ethnic differences in presentation and overall survival (OS) among patients diagnosed with ES before age 40 years. METHODS: Data from the Surveillance, Epidemiology, and End Results database identified 1715 patients aged <40 years who were diagnosed with ES between 1973 and 2005. Racial and ethnic group differences were compared using chi-square tests. OS was estimated by Kaplan-Meier analysis and compared using log-rank tests and Cox models. RESULTS: Black patients had significantly more soft-tissue tumors compared with white non-Hispanic patients (P<0001). Asian and white Hispanic patients were found to have an intermediate frequency of soft-tissue tumors that also differed from white non-Hispanic patients (P<.0001). White Hispanic patients presented with a higher proportion of larger tumors compared with white non-Hispanic patients (P = .042). Black patients tended to be older than white non-Hispanic patients (P = .012). Sex, frequency of pelvic tumors, and metastatic status did not appear to differ by ethnicity or race. OS was found to differ according to race and ethnicity. Even after controlling for known confounders, OS was significantly worse for black, Asian, and white Hispanic patients compared with white non-Hispanic patients (P = .0031, P = .0182, and P = .0051, respectively). CONCLUSIONS: Ethnic and racial differences in characteristics and outcomes of patients with ES do exist. Understanding the etiology of these differences will require further study. Cancer 2010;116:983-8. (C) 2010 American Cancer Society.
引用
收藏
页码:983 / 988
页数:6
相关论文
共 50 条
  • [1] ETHNIC AND RACIAL DIFFERENCES IN PATIENTS WITH EWING SARCOMA
    Worch, Jennifer
    Matthay, Katherine
    Goldsby, Robert
    DuBois, Steven
    PEDIATRIC BLOOD & CANCER, 2009, 52 (06) : 735 - 735
  • [2] Treatment outcomes of Japanese patients with Ewing sarcoma: differences between skeletal and extraskeletal Ewing sarcoma
    Takenaka, Satoshi
    Naka, Norifumi
    Obata, Hideto
    Joyama, Susumu
    Hamada, Ken-Ichiro
    Imura, Yoshinori
    Kakunaga, Shigeki
    Aoki, Yasuaki
    Ueda, Takafumi
    Araki, Nobuhito
    Yoshikawa, Hideki
    JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2016, 46 (06) : 522 - 528
  • [3] Ethnic disparities in pediatric Ewing sarcoma and osteosarcoma
    Green, Adam L.
    Ribeiro, Karina Braga
    Rodriguez-Galindo, Carlos
    JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (15)
  • [4] Racial/ethnic differences in patients with anemia and folate deficiency
    Gonzalez-Velez, Miguel
    Mead-Harvey, Carolyn
    Kosiorek, Heidi E.
    Kusne, Yael N.
    Rivera, Candido
    Bojanini, Leyla
    Northfelt, Donald W.
    Padrnos, Leslie J.
    INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 2020, 42 (04) : 403 - 410
  • [5] Racial and Ethnic Differences in Sarcoma Incidence Are Independent of Census-Tract Socioeconomic Status
    Diessner, Brandon J.
    Weigel, Brenda J.
    Murugan, Paari
    Zhang, Lin
    Poynter, Jenny N.
    Spector, Logan G.
    CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2020, 29 (11) : 2141 - 2148
  • [6] Dissecting racial and ethnic differences
    Risch, N
    NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (04): : 408 - 411
  • [7] Racial and ethnic differences in osteoporosis
    Thomas, Patricia A.
    JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS, 2007, 15 : S26 - S30
  • [8] Racial and Ethnic Differences in Breastfeeding
    McKinney, Chelsea O.
    Hahn-Holbrook, Jennifer
    Chase-Lansdale, P. Lindsay
    Ramey, Sharon L.
    Krohn, Julie
    Reed-Vance, Maxine
    Raju, Tonse N. K.
    Shalowitz, Madeleine U.
    PEDIATRICS, 2016, 138 (02)
  • [9] Racial and ethnic differences in hypertension
    Deborah S. Minor
    Marion R. Wofford
    Daniel W. Jones
    Current Atherosclerosis Reports, 2008, 10 : 121 - 127
  • [10] Racial and Ethnic Differences in Hypertension
    Minor, Deborah S.
    Wofford, Marion R.
    Jones, Daniel W.
    CURRENT ATHEROSCLEROSIS REPORTS, 2008, 10 (02) : 121 - 127