Robust asymmetric synthesis of unnatural alkenyl amino acids for conformationally constrained α-helix peptides

被引：16

作者：

Aillard, Boris ^{[1
]}

Robertson, Naomi S. ^{[1
]}

Baldwin, Adam R. ^{[1
]}

Robins, Siobhan ^{[1
]}

Jamieson, Andrew G. ^{[1
]}

机构：

[1] Univ Leicester, Dept Chem, Leicester LE1 7RH, Leics, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2014年 / 12卷 / 43期

基金：

英国工程与自然科学研究理事会;

关键词：

METATHESIS; GLYCINE; ALANINE; COMPLEXES; BASES;

D O I：

10.1039/c4ob01832j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The efficient asymmetric synthesis of unnatural alkenyl amino acids required for peptide 'stapling' has been achieved using alkylation of a fluorine-modified Ni-II Schiff base complex as the key step.

引用

页码：8775 / 8782

页数：8

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