Pd-Catalyzed Heck-Type Reaction: Synthesizing Highly Diastereoselective and Multiple Aryl-Substituted P-Ligands

被引：17
作者：
Li, Chong [1 ]
Qiang, Xiao-Yue [1 ]
Qi, Zhi-Chao [1 ]
Cao, Bin [1 ]
Li, Jing-Yu [1 ]
Yang, Shang-Dong [1 ,2 ]
机构：
[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China
[2] South China Univ Technol, Key Lab Funct Mol Engn Guangdong Prov, Guangzhou 510640, Guangdong, Peoples R China
来源：
ORGANIC LETTERS | 2019年 / 21卷 / 17期
关键词：
C-H ARYLATION; ASYMMETRIC ARYLATION; PALLADIUM(II) CATALYSIS; KINETIC RESOLUTION; BOND ACTIVATION; MODULAR ACCESS; EFFICIENT; 2,3-DIHYDROFURAN; CONSTRUCTION; SELECTIVITY;
D O I：
10.1021/acs.orglett.9b02697
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In this work, an efficient palladium-catalyzed Heck-type reaction was successfully used to synthesize a wide range of monoaryl- or diaryl-substituted P-ligands with excellent yields and diastereoselectivity (up to 98% yield, dr >20:1). The preliminary mechanistic studies demonstrated that it possibly underwent a cationic Heck reaction that was assisted by silver salt, and it revealed the significant role of P(O)Ar-2 for excellent yields and diastereoselectivity.
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收藏
页码：7138 / 7142
页数：5
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