Anti-hyperuricemic Effect of Fermented Barley Extract is Associated with Increased Urinary Uric Acid Excretion

被引：7
作者：
Hokazono, Hideki [1 ,2 ]
Omori, Toshiro [1 ]
Ono, Kazuhisa [2 ]
机构：
[1] Sanwa Shurui Co Ltd, Res Lab, Oita 8790495, Japan
[2] Hiroshima Univ, Grad Sch Adv Sci Matter, Dept Mol Biotechnol, Higashihiroshima 7398530, Japan
来源：
FOOD SCIENCE AND TECHNOLOGY RESEARCH | 2010年 / 16卷 / 04期
关键词：
fermented barley extract; uric acid; hyperuricemia; urate clearance; PURINE METABOLISM; SERUM; RATS; URATE; MICE; ENZYMES; WOMEN; MEN;
D O I：
10.3136/fstr.16.295
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Effects of a fermented barley extract P (FBEP) on uric acid (UA) metabolism in three hyperuricemia rat models were studied. First, the influence of FBEP on UA biosynthesis was examined using rats hypodermically administrated oxonic acid. Then, the influence of FBEP on dietary purine absorption was examined using rats fed a high dose of inosinic acid. Finally, the influence of FBEP on UA excretion was examined using adenine-administered rats. From the first two models, FBEP was found to be rarely, or not at all, involved in the biosynthesis of UA or absorption of nucleic acid. On the other hand, in the rats loaded with adenine, it was shown that the urinary UA of the high-dose FBEP group (4,000 mg/kg/day) was significantly elevated by 27% compared to the control group. In addition, the UA clearance value in the high-dose FBEP group was increased 2-fold compared to the control group. These results suggest that FBEP reduces serum UA by increasing urinary excretion of UA.
引用
收藏
页码：295 / 304
页数：10
相关论文
共 30 条
  • [1] Vitamin C Intake and the Risk of Gout in Men A Prospective Study
    Choi, Hyon K.
    Gao, Xiang
    Curhan, Gary
    [J]. ARCHIVES OF INTERNAL MEDICINE, 2009, 169 (05) : 502 - 507
  • [2] Molecular identification of a renal urate-anion exchanger that regulates blood urate levels
    Enomoto, A
    Kimura, H
    Chairoungdua, A
    Shigeta, Y
    Jutabha, P
    Cha, SH
    Hosoyamada, M
    Takeda, M
    Sekine, T
    Igarashi, T
    Matsuo, H
    Kikuchi, Y
    Oda, T
    Ichida, K
    Hosoya, T
    Shimokata, K
    Niwa, T
    Kanai, Y
    Endou, H
    [J]. NATURE, 2002, 417 (6887) : 447 - 452
  • [3] GARREL DR, 1991, AM J CLIN NUTR, V53, P665
  • [4] Extract of fermented barley attenuates chronic alcohol induced liver damage by increasing antioxidative activities
    Giriwono, Puspo E.
    Hashimoto, Takuya
    Ohsaki, Yusuke
    Shirakawa, Hitoshi
    Hokazono, Hideki
    Komai, Michio
    [J]. FOOD RESEARCH INTERNATIONAL, 2010, 43 (01) : 118 - 124
  • [5] Evolution of urate-degrading enzymes in animal peroxisomes
    Hayashi, S
    Fujiwara, S
    Noguchi, T
    [J]. CELL BIOCHEMISTRY AND BIOPHYSICS, 2000, 32 (1-3) : 123 - 129
  • [6] HIKITA M, 2000, TSUFU KAKUSAN TAISHA, V24, P139
  • [7] Effects of a Fermented Barley Extract on Subjects with Slightly High Serum Uric Acid or Mild Hyperuricemia
    Hokazono, Hideki
    Omori, Toshiro
    Yamamoto, Tetsuro
    Akaoka, Ieo
    Ono, Kazuhisa
    [J]. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2010, 74 (04) : 828 - 834
  • [8] Effects of Fermented Barley Extract on Antioxidant Status in Mice
    Hokazono, Hideki
    Omori, Toshiro
    Suzuki, Hiramitsu
    Ono, Kazuhisa
    [J]. FOOD SCIENCE AND TECHNOLOGY RESEARCH, 2009, 15 (06) : 599 - 604
  • [9] The effects of vitamin C supplementation on serum concentrations of uric acid - Results of a randomized controlled trial
    Huang, HY
    Appel, LJ
    Choi, MJ
    Gelber, AC
    Charleston, J
    Norkus, EP
    Miller, ER
    [J]. ARTHRITIS AND RHEUMATISM, 2005, 52 (06): : 1843 - 1847
  • [10] IMAMURA S, 1994, PURINE PYRIMIDINE ME, V18, P132
123