USP18 stimulates HCV production and blunts the antiviral effect of IFNα independent of its protease activity

被引：0
|
作者：
Chen, L. [1 ]
Sun, J. [1 ]
Heathcote, J. [1 ]
Edwards, A. [1 ]
McGilvray, I. [1 ]
机构：
[1] Univ Toronto, Toronto, ON M5S 1A1, Canada
来源：
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2010年 / 14卷
关键词：
D O I：
10.1016/S1201-9712(10)02402-1
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
引用
收藏
页码：S1 / S1
页数：1
相关论文
共 27 条
  • [1] USP18 PROMOTES HCV REPLICATION AND BLUNTS THE ANTIVIRAL EFFECT OF IFNA IN A PROTEASE-INDEPENDENT FASHION
    Chen, Limin
    Sun, Jing
    Meng, Xiangbin
    Heathcote, E. Jenny
    Edwards, Aled
    McGilvray, Ian
    HEPATOLOGY, 2008, 48 (04) : 399A - 399A
  • [2] The USP18 cysteine protease promotes HBV production independent of its protease activity
    Li, Yujia
    Yao, Min
    Duan, Xiaoqiong
    Ye, Haiyan
    Li, Shilin
    Chen, Limin
    Yang, Chunhui
    Chen, Yongjun
    VIROLOGY JOURNAL, 2020, 17 (01)
  • [3] The USP18 cysteine protease promotes HBV production independent of its protease activity
    Yujia Li
    Min Yao
    Xiaoqiong Duan
    Haiyan Ye
    Shilin Li
    Limin Chen
    Chunhui Yang
    Yongjun Chen
    Virology Journal, 17
  • [4] USP18 stimulates HCV production in vitro: a novel mechanism for HCV resistance to interferon therapy
    Chen, L. M.
    Sun, J.
    Lin, L. -T.
    Ma, M. X.
    Richardson, C.
    Edwards, A.
    Feld, J.
    McGilvray, I.
    INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2011, 15 : S14 - S14
  • [5] USP18 STIMULATES HCV PRODUCTION: UPREGULATION OF THE SURFACE ENTRY RECEPTOR CD81 IN VITRO
    Chen, L.
    Sun, J.
    Lin, L-T.
    Ma, M. X.
    Heathcote, J.
    Richardson, C.
    Edwards, A.
    Feld, J.
    Mcgilvray, I.
    JOURNAL OF HEPATOLOGY, 2011, 54 : S309 - S310
  • [6] THE USP18 CYSTEINE PROTEASE PROMOTES HCV INFECTION: IMPLICATIONS FOR TREATMENT RESPONSE
    Chen, Limin
    Qin, Bo
    Ma, Max Xuezhong M.
    Sun, Jing
    Lin, Liang-Tzung
    Richardson, Christopher D.
    Edwards, Aled
    Feld, Jordan J.
    McGilvray, Ian
    HEPATOLOGY, 2011, 54 : 1322A - 1322A
  • [7] Negative regulation of the RLR-mediated IFN signaling pathway by duck ubiquitin-specific protease 18 (USP18)
    Gu, Tiantian
    Lu, Lu
    An, Chen
    Zhang, Yu
    Wu, Xinsheng
    Xu, Qi
    Chen, Guohong
    JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 234 (04) : 3995 - 4004
  • [8] Silencing of USP18 potentiates the antiviral activity of interferon against hepatitis C virus infection
    Randall, Glenn
    Chen, Limin
    Panis, Maryline
    Fischer, Andrew K.
    Lindenbach, Brett D.
    Sun, Jing
    Heathcote, Jenny
    Rice, Charles M.
    Edwards, Aled M.
    McGilvray, Ian D.
    GASTROENTEROLOGY, 2006, 131 (05) : 1584 - 1591
  • [9] Virus-induced IFN-λ4 potently blocks IFN-α signaling by ISG15/USP18 in HCV infection
    Hong, Seon-Hui
    CYTOKINE, 2017, 100 : 33 - 33
  • [10] The ubiquitin specific protease USP18 is necessary but not sufficient for a hepatocyte IFN refractory state: Variable roles in Type 1 and Type III IFN responsiveness
    Cherepanov, Vera A.
    Alvandi, Zahra
    Chen, Limin
    Selzner, Nazia
    Renner, Eberhard L.
    McGilvray, Ian
    Feld, Jordan J.
    HEPATOLOGY, 2012, 56 : 1103A - 1103A
123