Three-dimensional computational fluid dynamics (CFD) study of the gas-particle circulation pattern within a fluidized bed granulator: By full factorial design of fluidization velocity and particle size

被引:17
作者
Liu, Huolong [1 ,2 ]
Yoon, Seongkyu [1 ]
Li, Mingzhong [2 ]
机构
[1] Univ Massachusetts, Dept Chem Engn, 1 Univ Ave, Lowell, MA 01850 USA
[2] De Montfort Univ, Sch Pharm, Leicester, Leics, England
关键词
Computational fluid dynamics; fluidization; fluidized bed granulator; full factorial design; gas-particle hydrodynamics; SPRAY GRANULATION; WET GRANULATION; COATING PROCESS; SCALE-UP; SIMULATION; SOLIDS; NUCLEATION; BREAKAGE; TRACKING; FLOW;
D O I
10.1080/07373937.2016.1230628
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
The fluidization velocity and mean particle size were selected to be numerically investigated pertaining to their effects on the gas-particle circulation pattern within a fluidized bed granulator by three-dimensional computational fluid dynamics (CFD) simulation applying an Eulerian-Eulerian two-fluid model. The CFD simulations were designed by full factorial design method and the developed CFD model was experimentally validated. The fluidization process was proved to reach a quasi-steady state. The gas-particle circulation pattern and particle concentration distribution were analyzed based on fluidization velocity and mean particle size. A mathematical model was developed to provide guidance on how to change fluidization level during one experiment.
引用
收藏
页码:1043 / 1058
页数:16
相关论文
共 48 条
[1]   Experimental and computational study on the bubble behavior in a 3-D fluidized bed [J].
Acosta-Iborra, A. ;
Sobrino, C. ;
Hernandez-Jimenez, F. ;
de Vega, M. .
CHEMICAL ENGINEERING SCIENCE, 2011, 66 (15) :3499-3512
[2]   Multiphase CFD modeling: Fluid dynamics aspects in scale-up of a fluidized-bed crystallizer [J].
Al-Rashed, Mohsen ;
Wojcik, Janusz ;
Plewik, Roch ;
Synowiec, Piotr ;
Kus, Agata .
CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION, 2013, 63 :7-15
[3]   A FLUID MECHANICAL DESCRIPTION OF FLUIDIZED BEDS [J].
ANDERSON, TB ;
JACKSON, R .
INDUSTRIAL & ENGINEERING CHEMISTRY FUNDAMENTALS, 1967, 6 (04) :527-&
[4]   Influence of process variable and physicochemical properties on the granulation mechanism of mannitol in a fluid bed top spray granulator [J].
Bouffard, J ;
Kaster, M ;
Dumont, H .
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2005, 31 (09) :923-933
[5]   CFD modeling of tapered circulating fluidized bed reactor risers: Hydrodynamic descriptions and chemical reaction responses [J].
Chalermsinsuwan, Benjapon ;
Kuchonthara, Prapan ;
Piumsomboon, Pornpote .
CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION, 2010, 49 (11) :1144-1160
[6]   Effect of circulating fluidized bed reactor riser geometries on chemical reaction rates by using CFD simulations [J].
Chalermsinsuwan, Benjapon ;
Kuchonthara, Prapan ;
Piumsomboon, Pornpote .
CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION, 2009, 48 (01) :165-177
[7]   Real-Time Monitoring of Gas-Solid Fluidized-Bed Granulation and Coating Process: Evolution of Particle Size, Fluidization Regime Transitions, and Psychometric Parameters [J].
da Silva, C. A. M. ;
Taranto, O. P. .
DRYING TECHNOLOGY, 2015, 33 (15-16) :1929-1948
[8]   Multiscale Simulation of Agglomerate Breakage in Fluidized Beds [J].
Dosta, Maksym ;
Antonyuk, Sergiy ;
Heinrich, Stefan .
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 2013, 52 (33) :11275-11281
[9]   Granule size control and targeting in pulsed spray fluid bed granulation [J].
Ehlers, Henrik ;
Liu, Anchang ;
Raikkonen, Heikki ;
Hatara, Juha ;
Antikainen, Osmo ;
Airaksinen, Sari ;
Heinamaki, Jyrki ;
Lou, Honxiang ;
Yliruusi, Jouko .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2009, 377 (1-2) :9-15
[10]   Impact of solid sizes on flow structure and particle motions in bubbling fluidization [J].
Fan, Xianfeng ;
Yang, Zhufang ;
Parker, David J. .
POWDER TECHNOLOGY, 2011, 206 (1-2) :132-138