In this paper, passenger and freight bi-purpose railway tied arch bridge is studied. Dynamic simulation train model is built on multibody system dynamics approach, and dynamic bridge model is built by using the finite element method. Coupled vibration response analysis of the tied arch bridge based on co-simulation technology of ANASYS and SIMPACK between multibody system dynamics and finite element is made. By calculating, analyses and assess are made of the bridge when trains are moving at different speeds. Results provide theoretical support and refer to the same type of bridge design.