Polysaccharides isolated from Phellinus baumii stimulate murine splenocyte proliferation and inhibit the lipopolysaccharide-induced nitric oxide production in RAW264.7 murine macrophages

被引：21
作者：
Chang, Z. Q.
Oh, B. C.
Rhee, M. H.
Kim, J. C.
Lee, S. P.
Park, S. C. [1 ]
机构：
[1] Kyungpook Natl Univ, Coll Vet Med, Taegu 702701, South Korea
[2] Korea Res Inst Biosci & Biotechnol, Microbial Genom Lab, Taejon 305600, South Korea
[3] Chonnam Natl Univ, Coll Vet Med, Kwangju 500757, South Korea
[4] Keimyung Univ, Ctr Tradit Microorganism Resources, Taegu 704701, South Korea
来源：
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY | 2007年 / 23卷 / 05期
关键词：
nitric oxide; Phellinus baumii; polysaccharide; splenocyte proliferation;
D O I：
10.1007/s11274-006-9277-3
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Polysaccharides isolated from Phellinus baumii (PBP) significantly enhanced both lipopolysaccharide (LPS)-induced B lymphocyte proliferation and concanavalin A (Con A)-induced T lymphocyte proliferation. However, PBP (12.5-100 mu g ml(-1)) significantly suppressed the LPS-induced nitric oxide (NO) production in RAW264.7 cells in a concentration-dependent manner. The maximal inhibition of PBP on NO production was 37.5% at 100 mu g ml(-1). These results provide useful in vitro information to explain the immunostimulating activity and anti-inflammatory activity of PBP.
引用
收藏
页码：723 / 727
页数：5
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