The advantageous role of annexin A1 in cardiovascular disease

被引：45
作者：
de Jong, Renske [1 ,2 ]
Leoni, Giovanna [1 ,2 ]
Drechsler, Maik [1 ,2 ,3 ]
Soehnlein, Oliver [1 ,2 ,3 ]
机构：
[1] Ludwig Maximilians Univ Munchen, Inst Cardiovasc Prevent, Munich, Germany
[2] Univ Amsterdam, Acad Med Ctr, Dept Pathol, Amsterdam, Netherlands
[3] DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany
来源：
CELL ADHESION & MIGRATION | 2017年 / 11卷 / 03期
关键词：
Ac2-26; annexin A1; atherosclerosis; cardiovascular diseases; leukocyte recruitment; myocardial infarction; stroke; resolution of inflammation; FORMYL-PEPTIDE RECEPTOR; MYOCARDIAL ISCHEMIA-REPERFUSION; LIPOCORTIN; L-SELECTIN; APOPTOTIC NEUTROPHILS; MONOCYTE RECRUITMENT; HUMAN-LEUKOCYTES; A(4) RECEPTOR; MAST-CELLS; IN-VIVO;
D O I：
10.1080/19336918.2016.1259059
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The inflammatory response protects the human body against infection and injury. However, uncontrolled and unresolved inflammation can lead to tissue damage and chronic inflammatory diseases. Therefore, active resolution of inflammation is essential to restore tissue homeostasis. This review focuses on the pro-resolving molecule annexin A1 (ANXA1) and its derived peptides. Mechanisms instructed by ANXA1 are multidisciplinary and affect leukocytes as well as endothelial cells and tissue resident cells like macrophages and mast cells. ANXA1 has an outstanding role in limiting leukocyte recruitment and different aspects of ANXA1 as modulator of the leukocyte adhesion cascade are discussed here. Additionally, this review details the therapeutic relevance of ANXA1 and its derived peptides in cardiovascular diseases since atherosclerosis stands out as a chronic inflammatory disease with impaired resolution and continuous leukocyte recruitment.
引用
收藏
页码：261 / 274
页数：14
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