Crosstalk between myeloid-derived suppressor cells and the immune system in prostate cancer: MDSCs and immune system in Prostate cancer

被引：34
作者：
Sanaei, Mohammad-Javad [1 ]
Salimzadeh, Loghman [2 ]
Bagheri, Nader [1 ]
机构：
[1] Shahrekord Univ Med Sci, Basic Hlth Sci Inst, Cellular & Mol Res Ctr, Shahrekord, Iran
[2] Natl Univ Singapore, Dept Med, Singapore, Singapore
来源：
JOURNAL OF LEUKOCYTE BIOLOGY | 2020年 / 107卷 / 01期
关键词：
Jak; Stat; mCRPC; PBMC; REGULATORY T-CELLS; NEUTROPHIL ELASTASE; IN-VIVO; MONOCLONAL-ANTIBODY; TUMOR MICROENVIRONMENT; CHRONIC INFLAMMATION; PERIPHERAL-BLOOD; DENDRITIC CELLS; GROWTH-FACTOR; PHASE-III;
D O I：
10.1002/JLB.4RU0819-150RR
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Prostate cancer is the second most common cancer and the fifth leading cause of cancer-associated death in men. Previous studies have revealed a surprising ability for an immature population of myeloid cells called myeloid-derived suppressor cells (MDSCs) in the commencement and development of many tumors, including those of prostate cancer. Herein, the molecular and cellular changes of MDSCs in prostate cancer in both human and nonhuman models are reviewed. The suppressive function of MDSCs are also discussed with a particular focus on the role of IL-6 and JAK/STAT3 signaling pathways in the induction of their suppressive activity. Ultimately, a brief review of MDSC-targeting approaches for potential cancer therapy is presented.
引用
收藏
页码：43 / 56
页数：14
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