Inhibition of diacylglycerol acyltransferase by prenylated flavonoids isolated from the stem bark of Maackia amurensis

被引：2

作者：

Li, Na ^{[1
]}

Zhang, Nan ^{[1
]}

Li, Jia-Lin ^{[1
]}

Du, Pei-Ge ^{[1
]}

Lee, Hyun-Sun ^{[2
]}

Cui, Long ^{[1
]}

机构：

[1] Beihua Univ, Coll Pharm, Jilin 132013, Peoples R China

[2] KRIBB, Mol Canc Res Ctr, Cheongwongun 363883, Chungbuk, South Korea

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2015年 / 17卷 / 02期

关键词：

DGAT; Leguminosae; Maackia amurensis; prenylated flavanone;

D O I：

10.1080/10286020.2014.960402

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new prenylated flavanone, erythraddison Z (1), together with eight known flavonoids (2-9), was isolated from the stem bark of Maackia amurensis. Their structures were elucidated on the basis of spectroscopic methods, including 1D and 2D NMR (COSY, HMQC, and HMBC) techniques. All the isolates, with the exception of 3, 6 and 7, strongly inhibited diacylglycerol acyltransferase activity in an in vitro assay with IC50 values ranging from 96.5 +/- 0.6 to 135.1 +/- 1.4 mu M.

引用

页码：178 / 181

页数：4

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