Monocyte cell membrane-derived nanoghosts for targeted cancer therapy

被引：122

作者：

Krishnamurthy, S. ^{[1
,2
]}

Gnanasammandhan, M. K. ^{[3
]}

Xie, C. ^{[1
,2
]}

Huang, K. ^{[3
]}

Cui, M. Y. ^{[1
,2
]}

Chan, J. M. ^{[1
,2
]}

机构：

[1] Nanyang Technol Univ, Sch Chem & Biomed Engn, Block N1-3,B4-10,70 Nanyang Dr, Singapore 637457, Singapore

[2] Nanyang Technol Univ, Lee Kong Chian Sch Med, Block N1-3,B4-10,70 Nanyang Dr, Singapore 637457, Singapore

[3] Natl Univ Singapore, Dept Biomed Engn, 9 Engn Dr 1,Block EA,03-12, Singapore 117575, Singapore

来源：

NANOSCALE | 2016年 / 8卷 / 13期

关键词：

ERYTHROCYTE-MEMBRANE; POLYMERIC NANOPARTICLES; DELIVERY; CARRIER; ADSORPTION; CIRCULATION; DOXORUBICIN; ADENOVIRUS;

D O I：

10.1039/c5nr07588b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Core-shell type 'nanoghosts' were synthesized with a drug-loaded biodegradable PLGA core and a monocyte cell membrane-derived shell. The nanoghosts were monodisperse with an average size <200 nm, and showed good serum stability for 120 h. Doxorubicin-loaded nanoghosts showed greater cellular uptake and cytotoxicity compared to non-coated nanoparticle controls in metastatic MCF-7 breast cancer cell lines.

引用

页码：6981 / 6985

页数：5

共 40 条

[11] Reconstructed Stem Cell Nanoghosts: A Natural Tumor Targeting Platform [J].

Furman, Naama E. Toledano ;

Lupu-Haber, Yael ;

Bronshtein, Tomer ;

Kaneti, Limor ;

Letko, Nitzan ;

Weinstein, Eyal ;

Baruch, Limor ;

Machluf, Marcelle .

NANO LETTERS, 2013, 13 (07) :3248-3255

[12] Surface Functionalization of Gold Nanoparticles with Red Blood Cell Membranes [J].

Gao, Weiwei ;

Hu, Che-Ming J. ;

Fang, Ronnie H. ;

Luk, Brian T. ;

Su, Jing ;

Zhang, Liangfang .

ADVANCED MATERIALS, 2013, 25 (26) :3549-3553

[13] Applications of carrier erythrocytes in delivery of biopharmaceuticals [J].

Hamidi, Mehrdad ;

Zarrin, Adbolhossein ;

Foroozesh, Mahshid ;

Mohammadi-Samani, Soliman .

JOURNAL OF CONTROLLED RELEASE, 2007, 118 (02) :145-160

[14]

Hu CMJ, 2013, NAT NANOTECHNOL, V8, P933, DOI [10.1038/NNANO.2013.254, 10.1038/nnano.2013.254]

[15] Erythrocyte-Inspired Delivery Systems [J].

Hu, Che-Ming J. ;

Fang, Ronnie H. ;

Zhang, Liangfang .

ADVANCED HEALTHCARE MATERIALS, 2012, 1 (05) :537-547

[16] Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform [J].

Hu, Che-Ming J. ;

Zhang, Li ;

Aryal, Santosh ;

Cheung, Connie ;

Fang, Ronnie H. ;

Zhang, Liangfang .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (27) :10980-10985

[17] Efficient antitumor effects of carrier cells loaded with a fiber-substituted conditionally replicating adenovirus on CAR-negative tumor cells [J].

Iguchi, K. ;

Sakurai, F. ;

Tomita, K. ;

Katayama, K. ;

Yamaguchi, T. ;

Kawabata, K. ;

Tagawa, M. ;

Kawabata, M. ;

Shirakawa, T. ;

Mizuguchi, H. .

CANCER GENE THERAPY, 2012, 19 (02) :118-125

[18] The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices [J].

Jain, RA .

BIOMATERIALS, 2000, 21 (23) :2475-2490

[19] Engineering lymphocyte subsets: tools, trials and tribulations [J].

June, Carl H. ;

Blazar, Bruce R. ;

Riley, James L. .

NATURE REVIEWS IMMUNOLOGY, 2009, 9 (10) :704-716

[20] Lipid-coated polymeric nanoparticles for cancer drug delivery [J].

Krishnamurthy, Sangeetha ;

Vaiyapuri, Rajendran ;

Zhang, Liangfang ;

Chan, Juliana M. .

BIOMATERIALS SCIENCE, 2015, 3 (07) :923-936

← 1 2 3 4 →