Monocyte cell membrane-derived nanoghosts for targeted cancer therapy

被引：122

作者：

Krishnamurthy, S. ^{[1
,2
]}

Gnanasammandhan, M. K. ^{[3
]}

Xie, C. ^{[1
,2
]}

Huang, K. ^{[3
]}

Cui, M. Y. ^{[1
,2
]}

Chan, J. M. ^{[1
,2
]}

机构：

[1] Nanyang Technol Univ, Sch Chem & Biomed Engn, Block N1-3,B4-10,70 Nanyang Dr, Singapore 637457, Singapore

[2] Nanyang Technol Univ, Lee Kong Chian Sch Med, Block N1-3,B4-10,70 Nanyang Dr, Singapore 637457, Singapore

[3] Natl Univ Singapore, Dept Biomed Engn, 9 Engn Dr 1,Block EA,03-12, Singapore 117575, Singapore

来源：

NANOSCALE | 2016年 / 8卷 / 13期

关键词：

ERYTHROCYTE-MEMBRANE; POLYMERIC NANOPARTICLES; DELIVERY; CARRIER; ADSORPTION; CIRCULATION; DOXORUBICIN; ADENOVIRUS;

D O I：

10.1039/c5nr07588b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Core-shell type 'nanoghosts' were synthesized with a drug-loaded biodegradable PLGA core and a monocyte cell membrane-derived shell. The nanoghosts were monodisperse with an average size <200 nm, and showed good serum stability for 120 h. Doxorubicin-loaded nanoghosts showed greater cellular uptake and cytotoxicity compared to non-coated nanoparticle controls in metastatic MCF-7 breast cancer cell lines.

引用

页码：6981 / 6985

页数：5

共 40 条

[1] ADSORPTION-ISOTHERM FOR DOXORUBICIN ON ERYTHROCYTE-MEMBRANE [J].

ALACHI, A ;

BOROUJERDI, M .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1990, 16 (08) :1325-1338

[2] PHARMACOKINETICS AND TISSUE UPTAKE OF DOXORUBICIN ASSOCIATED WITH ERYTHROCYTE-MEMBRANE - ERYTHROCYTE-GHOSTS VS ERYTHROCYTE-VESICLES [J].

ALACHI, A ;

BOROUJERDI, M .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1990, 16 (15) :2199-2219

[3] Delivering Nanoparticles to Lungs while Avoiding Liver and Spleen through Adsorption on Red Blood Cells [J].

Anselmo, Aaron C. ;

Gupta, Vivek ;

Zern, Blaine J. ;

Pan, Daniel ;

Zakrewsky, Michael ;

Muzykantov, Vladimir ;

Mitragotri, Samir .

ACS NANO, 2013, 7 (12) :11129-11137

[4] Prolonged circulation of large polymeric nanoparticles by non-covalent adsorption on erythrocytes [J].

Chambers, E ;

Mitragotri, S .

JOURNAL OF CONTROLLED RELEASE, 2004, 100 (01) :111-119

[5]

Chambers E, 2007, EXP BIOL MED, V232, P958

[6] Spatiotemporal controlled delivery of nanoparticles to injured vasculature [J].

Chan, Juliana M. ;

Zhang, Liangfang ;

Tong, Rong ;

Ghosh, Debuyati ;

Gao, Weiwei ;

Liao, Grace ;

Yuet, Kai P. ;

Gray, David ;

Rhee, June-Wha ;

Cheng, Jianjun ;

Golomb, Gershon ;

Libby, Peter ;

Langer, Robert ;

Farokhzad, Omid C. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (05) :2213-2218

[7] Macrophage Binding to Receptor VCAM-1 Transmits Survival Signals in Breast Cancer Cells that Invade the Lungs [J].

Chen, Qing ;

Zhang, Xiang H. -F. ;

Massague, Joan .

CANCER CELL, 2011, 20 (04) :538-549

[8] Cell-Based Drug Delivery Devices Using Phagocytosis-Resistant Backpacks [J].

Doshi, Nishit ;

Swiston, Albert J. ;

Gilbert, Jonathan B. ;

Alcaraz, Maria L. ;

Cohen, Robert E. ;

Rubner, Michael F. ;

Mitragotri, Samir .

ADVANCED MATERIALS, 2011, 23 (12) :H105-H109

[9] Cancer Cell Membrane-Coated Nanoparticles for Anticancer Vaccination and Drug Delivery [J].

Fang, Ronnie H. ;

Hu, Che-Ming J. ;

Luk, Brian T. ;

Gao, Weiwei ;

Copp, Jonathan A. ;

Tai, Yiyin ;

O'Connor, Derek E. ;

Zhang, Liangfang .

NANO LETTERS, 2014, 14 (04) :2181-2188

[10] Macrophage protection by addition of glutathione (GSH)-loaded erythrocytes to AZT and DDI in a murine AIDS model [J].

Fraternale, A ;

Casabianca, A ;

Orlandi, C ;

Cerasi, A ;

Chiarantini, L ;

Brandi, G ;

Magnani, M .

ANTIVIRAL RESEARCH, 2002, 56 (03) :263-272

← 1 2 3 4 →