Monocyte cell membrane-derived nanoghosts for targeted cancer therapy

被引：117

作者：

Krishnamurthy, S. ^{[1
,2
]}

Gnanasammandhan, M. K. ^{[3
]}

Xie, C. ^{[1
,2
]}

Huang, K. ^{[3
]}

Cui, M. Y. ^{[1
,2
]}

Chan, J. M. ^{[1
,2
]}

机构：

[1] Nanyang Technol Univ, Sch Chem & Biomed Engn, Block N1-3,B4-10,70 Nanyang Dr, Singapore 637457, Singapore

[2] Nanyang Technol Univ, Lee Kong Chian Sch Med, Block N1-3,B4-10,70 Nanyang Dr, Singapore 637457, Singapore

[3] Natl Univ Singapore, Dept Biomed Engn, 9 Engn Dr 1,Block EA,03-12, Singapore 117575, Singapore

来源：

NANOSCALE | 2016年 / 8卷 / 13期

关键词：

ERYTHROCYTE-MEMBRANE; POLYMERIC NANOPARTICLES; DELIVERY; CARRIER; ADSORPTION; CIRCULATION; DOXORUBICIN; ADENOVIRUS;

D O I：

10.1039/c5nr07588b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Core-shell type 'nanoghosts' were synthesized with a drug-loaded biodegradable PLGA core and a monocyte cell membrane-derived shell. The nanoghosts were monodisperse with an average size <200 nm, and showed good serum stability for 120 h. Doxorubicin-loaded nanoghosts showed greater cellular uptake and cytotoxicity compared to non-coated nanoparticle controls in metastatic MCF-7 breast cancer cell lines.

引用

页码：6981 / 6985

页数：5

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