Transaminations with isopropyl amine: equilibrium displacement with yeast alcohol dehydrogenase coupled to in situ cofactor regeneration

被引：107

作者：

Cassimjee, Karim Engelmark ^{[1
]}

Branneby, Cecilia ^{[2
]}

Abedi, Vahak ^{[3
]}

Wells, Andrew ^{[4
]}

Berglund, Per ^{[1
]}

机构：

[1] Royal Inst Technol KTH, AlbaNova Univ Ctr, Sch Biotechnol, Div Biochem, SE-10691 Stockholm, Sweden

[2] Cambrex Karlskoga AB, SE-69185 Karlskrona, Sweden

[3] AstraZeneca R&D, SE-15185 Sodertalje, Sweden

[4] AstraZeneca Global Proc R&D, Loughborough LE11 5RH, Leics, England

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 30期

关键词：

OPTICALLY-ACTIVE AMINES; ASYMMETRIC-SYNTHESIS; OMEGA-TRANSAMINASES; CHIRAL AMINES;

D O I：

10.1039/c0cc00050g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enantiopure chiral amines synthesis using omega-transaminases is hindered by an unfavourable equilibrium, but when using isopropylamine as the amine donor the equilibrium can be completely displaced by using a specific dehydrogenase in situ for removal of formed acetone.

引用

页码：5569 / 5571

页数：3

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