ALZHEIMER DISEASE Rodent models for Alzheimer disease

被引：242

作者：

Goetz, Juergen ^{[1
]}

Bodea, Liviu-Gabriel ^{[1
]}

Goedert, Michel ^{[2
]}

机构：

[1] Univ Queensland, QBI, CJCADR, St Lucia Campus, Brisbane, Qld, Australia

[2] MRC, Lab Mol Biol, Cambridge, England

来源：

NATURE REVIEWS NEUROSCIENCE | 2018年 / 19卷 / 10期

基金：

英国医学研究理事会;

关键词：

AMYLOID PRECURSOR PROTEIN; TAU-TRANSGENIC MICE; TRAUMATIC BRAIN-INJURY; SENESCENCE-ACCELERATED MOUSE; SPATIAL-LEARNING DEFICITS; GENOME-WIDE ASSOCIATION; INTRACELLULAR A-BETA; KNOCK-IN MICE; FRONTOTEMPORAL DEMENTIA; NEURODEGENERATIVE DISEASES;

D O I：

10.1038/s41583-018-0054-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Animal models are indispensable tools for Alzheimer disease (AD) research. Over the course of more than two decades, an increasing number of complementary rodent models has been generated. These models have facilitated testing hypotheses about the aetiology and progression of AD, dissecting the associated pathomechanisms and validating therapeutic interventions, thereby providing guidance for the design of human clinical trials. However, the lack of success in translating rodent data into therapeutic outcomes may challenge the validity of the current models. This Review critically evaluates the genetic and non-genetic strategies used in AD modelling, discussing their strengths and limitations, as well as new opportunities for the development of better models for the disease.

引用

页码：583 / 598

页数：16

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