Inter-institutional survival heterogeneity in chemoradiation therapy for esophageal cancer: exploratory analysis of the JCOG0303 study

被引：2

作者：

Hamamoto, Yasuo ^{[1
]}

Mizusawa, Junki ^{[2
]}

Katayama, Hiroshi ^{[2
]}

Nakamura, Kenichi ^{[2
]}

Kato, Ken ^{[3
]}

Tsubosa, Yasuhiro ^{[4
]}

Ishikura, Satoshi ^{[5
]}

Igaki, Hiroyasu ^{[6
]}

Shinoda, Masayuki ^{[7
]}

Fukuda, Haruhiko ^{[2
]}

Kitagawa, Yuko ^{[8
]}

Ando, Nobutoshi ^{[9
]}

机构：

[1] Keio Univ, Sch Med, Ctr Canc, Tokyo, Japan

[2] Natl Canc Ctr, Operat Off, Japan Clin Oncol Grp Data Ctr, Tokyo 104, Japan

[3] Natl Canc Ctr, Gastrointestinal Med Oncol Div, 1-1 Tsukiji 5 chome, Tokyo, Japan

[4] Shizuoka Canc Ctr, Esophageal Surg Div, Shizuoka, Japan

[5] Koshigaya Municipal Hosp, Dept Radiol, Koshigaya, Japan

[6] Natl Canc Ctr, Esophageal Surg Div, 1-1 Tsukiji 5 chome, Tokyo, Japan

[7] Aichi Canc Ctr, Dept Thorac Surg, Nagoya, Aichi 464, Japan

[8] Keio Univ, Sch Med, Dept Surg, Tokyo 160, Japan

[9] Int Goodwill Hosp, Yokohama, Kanagawa, Japan

来源：

JAPANESE JOURNAL OF CLINICAL ONCOLOGY | 2016年 / 46卷 / 04期

关键词：

heterogeneity; esophageal cancer; chemoradiotherapy; SQUAMOUS-CELL CARCINOMA; CHEMORADIOTHERAPY; RADIOTHERAPY; SURGERY;

D O I：

10.1093/jjco/hyv211

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

It is important to examine variation in the treatment effects of patients with esophageal cancer in order to generalize treatment outcomes. We aimed to investigate the range of prognostic differences among hospitals in the treatment of locally advanced esophageal cancer. The JCOG0303 study compared the efficacy of radiotherapy plus low-dose cisplatin and 5-fluorouracil with that of high-dose cisplatin and 5-fluorouracil for unresectable esophageal cancer. Of 32 institutions participating in the JCOG0303 study, the 18 institutions that enrolled three or more patients were included in this study. We predicted the 1-year survival in each institution by using a mixed-effect model. We found that the predicted 1-year survival in the 18 institutions with three or more patients was a median of 60.9%, with a range of 60.9-60.9%. This study is the first to investigated heterogeneity of survival in patients who received definitive chemoradiotherapy for locally advanced esophageal squamous cell carcinoma.

引用

页码：389 / 392

页数：4

共 16 条

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