Volatile Constituents of the Leaf Essential Oil of Crinum asiaticum and their Antimicrobial and Cytotoxic Activities

被引：12

作者：

Tan, Wen-Nee ^{[1
]}

Shahbudin, Farah Nabilah ^{[2
]}

Kamal, Nik Nur Syazni Nik Mohamed ^{[3
]}

Tong, Woei-Yenn ^{[4
]}

Leong, Chean-Ring ^{[4
]}

Lim, Jun-Wei ^{[5
]}

机构：

[1] Univ Sains Malaysia, Sch Distance Educ, Chem Sect, Minden 11800, Penang, Malaysia

[2] Univ Sains Malaysia, Sch Chem Sci, Minden 11800, Penang, Malaysia

[3] Univ Sains Malaysia, Cluster Integrat Med, Adv Med & Dent Inst, Kepala Batas 13200, Penang, Malaysia

[4] Univ Kuala Lumpur, Malaysian Inst Chem & Bioengn Technol, Alor Gajah 78000, Melaka, Malaysia

[5] Univ Teknol PETRONAS, Dept Fundamental & Appl Sci, Seri Iskandar 32610, Perak, Malaysia

来源：

JOURNAL OF ESSENTIAL OIL BEARING PLANTS | 2019年 / 22卷 / 04期

关键词：

Crinum asiaticum; essential oil; MCF-7; antimicrobial activities; CHEMICAL-COMPOSITION; OLEIC-ACID; BREAST;

D O I：

10.1080/0972060X.2019.1683079

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Crinum asiaticum, locally known as ?bunga tembaga suasa? in Malaysia has been used since ancient ages in folk medicine. The present study was aimed to examine the volatile constituents of the leaf essential oil of C. asiaticum and their antimicrobial and cytotoxic activities. The chemical constituents obtained by hydrodistillation were analyzed using GC and GC/MS. Seventeen constituents were identified in the leaf essential oil, representing 93.14 % of the sample. The major constituents found in the leaf essential oil were 1-hexadecanol (27.69 %), oleic acid (23.32 %) and methyl octadecanoate (12.45 %). In the in vitro MTT assay, the leaf essential oil induced cytotoxic effects of 20-25 % towards MCF-7 cells within 24-72 h of incubation period at 20-70 mg/ml. Moreover, the leaf essential oil also showed antimicrobial activity against Shigella boydii, Candida albicans and Rhizopus sp. with MIC values of 1.25, 0.078 and 0.078 mg/ml, respectively.

引用

页码：947 / 954

页数：8

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