Synovial cellular and molecular markers in rheumatoid arthritis

被引：91

作者：

Amin, M. Asif ^{[1
,2
]}

Fox, David A. ^{[1
,2
]}

Ruth, Jeffrey H. ^{[1
,2
]}

机构：

[1] Univ Michigan, Div Rheumatol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Clin Autoimmun Ctr Excellence, Ann Arbor, MI 48109 USA

来源：

SEMINARS IN IMMUNOPATHOLOGY | 2017年 / 39卷 / 04期

关键词：

FIBROBLAST-LIKE SYNOVIOCYTES; ADJUVANT-INDUCED ARTHRITIS; PERIPHERAL-BLOOD MONOCYTES; COLLAGEN-INDUCED ARTHRITIS; COLONY-STIMULATING FACTORS; ACTIVATED T-CELLS; DNA-BINDING; MACROPHAGE ACTIVATION; CHEMOTACTIC CYTOKINE; GM-CSF;

D O I：

10.1007/s00281-017-0631-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The profound alterations in the structure, cellular composition, and function of synovial tissue in rheumatoid arthritis (RA) are the basis for the persistent inflammation and cumulative joint destruction that are hallmarks of this disease. In RA, the synovium develops characteristics of a tertiary lymphoid organ, with extensive infiltration of lymphocytes and myeloid cells. Concurrently, the fibroblast-like synoviocytes undergo massive hyperplasia and acquire a tissue-invasive phenotype. In this review, we summarize key components of these processes, focusing on recently-described roles of selected molecular markers of these cellular components of RA synovitis.

引用

页码：385 / 393

页数：9

共 106 条

[11]

2-5

[12]

Bresnihan B, 2007, J RHEUMATOL, V34, P620

[13]

Campbell IK, 2000, J LEUKOCYTE BIOL, V68, P144

[14]

Cauli A, 1997, BRIT J RHEUMATOL, V36, P935

[15] Blockade of collagen-induced arthritis post-onset by antibody to granulocyte-macrophage colony-stimulating factor (GM-CSF): requirement for GM-CSF in the effector phase of disease [J].

Cook, AD ;

Braine, EL ;

Campbell, IK ;

Rich, MJ ;

Hamilton, JA .

ARTHRITIS RESEARCH, 2001, 3 (05) :293-298

[16] Treg Cells in Rheumatoid Arthritis: An Update [J].

Cooles, Faye A. H. ;

Isaacs, John D. ;

Anderson, Amy E. .

CURRENT RHEUMATOLOGY REPORTS, 2013, 15 (09)

[17] G-CSF and GM-CSF as therapeutic targets in rheumatoid arthritis [J].

Cornish, Ann L. ;

Campbell, Ian K. ;

McKenzie, Brent S. ;

Chatfield, Simon ;

Wicks, Ian P. .

NATURE REVIEWS RHEUMATOLOGY, 2009, 5 (10) :554-559

[18] Differential effects of infliximab on absolute circulating blood leucocyte counts of innate immune cells in early and late rheumatoid arthritis patients [J].

Coulthard, L. R. ;

Geiler, J. ;

Mathews, R. J. ;

Church, L. D. ;

Dickie, L. J. ;

Cooper, D. L. ;

Wong, C. ;

Savic, S. ;

Bryer, D. ;

Buch, M. H. ;

Emery, P. ;

Morgan, A. W. ;

McDermott, M. F. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2012, 170 (01) :36-46

[19] CYCLOOXYGENASE-1 AND CYCLOOXYGENASE-2 EXPRESSION IN RHEUMATOID SYNOVIAL TISSUES - EFFECTS OF INTERLEUKIN-1-BETA, PHORBOL ESTER, AND CORTICOSTEROIDS [J].

CROFFORD, LJ ;

WILDER, RL ;

RISTIMAKI, AP ;

SANO, H ;

REMMERS, EF ;

EPPS, HR ;

HLA, T .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (03) :1095-1101

[20] Human CD14dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors [J].

Cros, Jerome ;

Cagnard, Nicolas ;

Woollard, Kevin ;

Patey, Natacha ;

Zhang, Shen-Ying ;

Senechal, Brigitte ;

Puel, Anne ;

Biswas, Subhra K. ;

Moshous, Despina ;

Picard, Capucine ;

Jais, Jean-Philippe ;

D'Cruz, David ;

Casanova, Jean-Laurent ;

Trouillet, Celine ;

Geissmann, Frederic .

IMMUNITY, 2010, 33 (03) :375-386

← 1 2 3 4 5 6 7 8 9 10 →