Synovial cellular and molecular markers in rheumatoid arthritis

被引：91
作者：
Amin, M. Asif [1 ,2 ]
Fox, David A. [1 ,2 ]
Ruth, Jeffrey H. [1 ,2 ]
机构：
[1] Univ Michigan, Div Rheumatol, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Clin Autoimmun Ctr Excellence, Ann Arbor, MI 48109 USA
来源：
SEMINARS IN IMMUNOPATHOLOGY | 2017年 / 39卷 / 04期
关键词：
FIBROBLAST-LIKE SYNOVIOCYTES; ADJUVANT-INDUCED ARTHRITIS; PERIPHERAL-BLOOD MONOCYTES; COLLAGEN-INDUCED ARTHRITIS; COLONY-STIMULATING FACTORS; ACTIVATED T-CELLS; DNA-BINDING; MACROPHAGE ACTIVATION; CHEMOTACTIC CYTOKINE; GM-CSF;
D O I：
10.1007/s00281-017-0631-3
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The profound alterations in the structure, cellular composition, and function of synovial tissue in rheumatoid arthritis (RA) are the basis for the persistent inflammation and cumulative joint destruction that are hallmarks of this disease. In RA, the synovium develops characteristics of a tertiary lymphoid organ, with extensive infiltration of lymphocytes and myeloid cells. Concurrently, the fibroblast-like synoviocytes undergo massive hyperplasia and acquire a tissue-invasive phenotype. In this review, we summarize key components of these processes, focusing on recently-described roles of selected molecular markers of these cellular components of RA synovitis.
引用
收藏
页码：385 / 393
页数：9
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