Antitumor effect induced by dendritic cell (DC)-based immunotherapy against peritoneal dissemination of the hamster pancreatic cancer

被引：14
作者：
Takigawa, Y
Akiyama, Y
Maruyama, K
Sugiyama, K
Uchida, E
Kosuge, T
Ueda, M
Kitajima, M
Yamaguchi, K
机构：
[1] Shizuoka Canc Ctr, Res Inst, Div Immunotherapy, Nagaizumi, Shizuoka 4118777, Japan
[2] Natl Canc Ctr, Res Inst, Div Growth Factor, Tokyo 104, Japan
[3] Univ Texas, Med Branch, Dept Microbiol & Immunol, Galveston, TX 77550 USA
[4] Nippon Med Coll, Dept Surg 1, Tokyo 113, Japan
[5] Cent Hosp, Natl Canc Ctr, Dept Surg, Tokyo, Japan
[6] Keio Univ, Sch Med, Dept Surg, Tokyo 160, Japan
来源：
CANCER LETTERS | 2004年 / 215卷 / 02期
关键词：
hamster DC; pancreatic cancer; orthotopic model; peritoneal dissemination; DC migration; cytotoxic T-lymphocyte;
D O I：
10.1016/j.canlet.2004.07.007
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Establishing a method to control peritoneal dissemination is one of the most pressing issues in the postsurgical treatment of pancreatic cancer. In the present study, we investigated the effect of dendritic cell (DC)-based immunotherapy on peritoneal disseminations of hamster pancreatic cancer cells, PGHAM-1. After the orthotopically inoculation of 2 X 10(6) PGHAM-1 cells, DC pulsed with PGHAM-1-derived tumor lysates, DC alone or PBS as a vehicle was injected intraperitoneally (i.p.) three times at weekly intervals. The group treated with DC or DC + lysate was found to have smaller disseminated tumors than the vehicle-treated. In addition, mean survival time in the DC + lysate groups was significantly longer than the PBS group. These findings suggested that DC-based immunotherapy might be efficient for the treatment of peritoneal disseminations of the pancreatic cancer. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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收藏
页码：179 / 186
页数：8
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