Peroxisome Proliferator-Activated Receptor (PPAR) Gamma Agonists as Therapeutic Agents for Cardiovascular Disorders: Focus on Atherosclerosis

被引：44
作者：
Ivanova, Ekaterina A. [1 ]
Myasoedova, Veronika A. [2 ,3 ]
Melnichenko, Alexandra A. [2 ]
Orekhov, Alexander N. [2 ,4 ]
机构：
[1] Katholieke Univ Leuven, Dept Dev & Regenerat, B-3000 Leuven, Belgium
[2] Russian Acad Sci, Inst Gen Pathol & Pathophysiol, Lab Angiopathol, Moscow 125315, Russia
[3] IRCCS, Ctr Cardiol Monzino, Unit Atherosclerosis Prevent, Via Carlo Parea 4, I-20138 Milan, Italy
[4] Skolkovo Innovat Ctr, Inst Atherosclerosis Res, Moscow 121609, Russia
来源：
CURRENT PHARMACEUTICAL DESIGN | 2017年 / 23卷 / 07期
基金：
俄罗斯基础研究基金会;
关键词：
Peroxisome proliferation-activated receptor gamma (PPAR gamma); cardiovascular disorders; cardiovascular surgery; atherosclerosis; ISCHEMIA-REPERFUSION INJURY; SMOOTH-MUSCLE CELLS; IN-STENT RESTENOSIS; GROWTH-FACTOR-BETA; INSULIN-RESISTANCE; DIABETIC-RATS; ENDOTHELIAL FUNCTION; NONDIABETIC PATIENTS; ANEURYSM SYNDROMES; GENE-EXPRESSION;
D O I：
10.2174/1381612823666161118145850
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Peroxisome proliferation-activated receptors (PPARs) are ligand-activated transcription factors that mainly regulate genes responsible for fatty acid (FA) and energy metabolism. There are three members of the PPAR family, PPAR-alpha, PPAR-beta/delta and PPAR-gamma All three isoforms have therapeutic potential for treatment of cardiovascular disorders, and PPAR agonists are currently being actively studied in pre-clinical and clinical trials. PPAR. agonists, main tissue expressing isoform, have potential to influence on inflammation processes, reduce oxidative stress, improve endothelial function and plays an important role in lipid metabolism. PPAR-gamma agonists are used as insulin sensitizers for treatment of diabetes; however, there is accumulating evidence that their clinical application can be broadened. The wide spectrum of PPAR-gamma activation effects may be beneficial for treatment of various cardiovascular conditions as atherosclerosis, hypertension and aortic aneurysm, including surgical interventions. In this Review we will discuss the implication of PPAR-gamma in the cardiovascular system and potential role of PPAR-. agonists in treatment of conditions associated with high cardiovascular risks.
引用
收藏
页码：1119 / 1124
页数：6
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