YES, a novel therapeutic target in hepatocellular carcinoma

被引：1
|
作者：
Lapouge, Marjorie [1 ]
Meloche, Sylvain [1 ,2 ,3 ]
机构：
[1] Inst Res Immunol & Canc, Signaling & Cell Growth Lab, Montreal, PQ, Canada
[2] Univ Montreal, Dept Pharmacol & Physiol, Montreal, PQ, Canada
[3] Univ Montreal, Fac Med, Mol Biol Program, Montreal, PQ, Canada
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2022年 / 9卷 / 01期
关键词：
YES; SRC-family kinases; YAP/TAZ; hepatocellular carcinoma; kinase inhibitors; SRC FAMILY KINASES;
D O I：
10.1080/23723556.2022.2069993
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Identification of dominant, actionable oncogenic signaling pathways is key to guide the development of new targeted treatments for advanced-stage hepatocellular carcinoma (HCC). We have recently unveiled a novel YES-YAP/TAZ signaling axis involved in liver cancer development. Our study identifies the tyrosine kinase YES as a potential therapeutic target in HCC.
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页数：3
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