THE HETEROGENEITY OF VENTRAL TEGMENTAL AREA NEURONS: PROJECTION FUNCTIONS IN A MOOD-RELATED CONTEXT

被引：75

作者：

Walsh, J. J. ^{[1
,2
]}

Han, M. H. ^{[1
,3
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Pharmacol & Syst Therapeut, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Grad Sch Biomed Sci, Neurosci Program, New York, NY 10029 USA

[3] Icahn Sch Med Mt Sinai, Friedman Brain Inst, Dept Neurosci, New York, NY 10029 USA

来源：

NEUROSCIENCE | 2014年 / 282卷

关键词：

ventral tegmental area; projection functions; animal models; mood disorders; neural circuits; depression; MIDBRAIN DOPAMINE NEURONS; LONG-TERM POTENTIATION; SOCIAL DEFEAT; ELECTROPHYSIOLOGICAL PROPERTIES; GLUTAMATERGIC NEURONS; PREFRONTAL CORTEX; REWARD CIRCUIT; IN-VITRO; RAT; SYNAPSES;

D O I：

10.1016/j.neuroscience.2014.06.006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The ventral tegmental area (VTA) in the brain's reward circuitry is composed of a heterogeneous population of dopamine, GABA, and glutamate neurons that play important roles in mediating mood-related functions including depression. These neurons project to different brain regions, including the nucleus accumbens (NAc), the medial prefrontal cortex (mPFC), and the amygdala. The functional understanding of these projection pathways has been improved since the extensive use of advanced techniques such as viral-mediated gene transfer, cell-type-specific neurophysiology and circuit-probing optogenetics. In this article, we will discuss the recent progress in understanding these VTA projection-specific functions, focusing on mood-related disorders. This article is part of a Special Issue entitled: Ventral Tegmentum & Dopamine. Published by Elsevier Ltd. on behalf of IBRO.

引用

页码：101 / 108

页数：8

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