p73: Structure and function

被引：20

作者：

Ichimiya, S

Nakagawara, A

Sakuma, Y

Kimura, S

Ikeda, T

Satoh, M

Takahashi, N

Sato, N

Mori, M

机构：

[1] Sapporo Med Univ, Sch Med, Dept Pathol, Chuo Ku, Sapporo, Hokkaido 0608556, Japan

[2] Chiba Canc Ctr, Res Inst, Div Biochem, Chiba, Japan

[3] Sapporo Med Univ, Inst Marine Biomed, Rishirifuji, Hokkaido, Japan

来源：

PATHOLOGY INTERNATIONAL | 2000年 / 50卷 / 08期

关键词：

p53; p73; anti-cancer drug;

D O I：

10.1046/j.1440-1827.2000.01090.x

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Alteration of the p53 tumor suppressor gene is a common, if not general, observation in human malignant tumors. p73 Is a novel member of the p53 family at chromosome 1p36.3, at which locus frequent defects are seen in many tumors including neuroblastoma. Besides structural similarities, the fact that p73 functions in the regulation of the cell cycle and apoptosis promotes the expansion of the research field concerning p53-associated tumor progression. In this paper, we review the structure and function of p73 as well as the mutational status in various human tumors. In addition, possibilities for new therapeutic applications with p73 for cancer cell control are discussed.

引用

收藏

页码：589 / 593

页数：5

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