Identification and Validation of Immune-Related Methylation Clusters for Predicting Immune Activity and Prognosis in Breast Cancer

被引：3
作者：
Yang, Anli [1 ]
Zhou, Ying [2 ]
Kong, Yanan [1 ]
Wei, Xiaoli [3 ]
Ye, Feng [1 ]
Zhang, Lijuan [1 ]
Zhong, Xian [4 ]
Li, Mingyue [5 ]
Lu, Shilin [6 ]
An, Xin [3 ]
Xiao, Weikai [1 ,7 ]
机构：
[1] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, Dept Breast Oncol, State Key Lab Oncol South China,Canc Ctr, Guangzhou, Peoples R China
[2] Haizhu Dist Ctr Dis Control & Prevent, Dept Infect Dis & Endem Dis Control, Guangzhou, Peoples R China
[3] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, Dept Med Oncol, State Key Lab Oncol South China,Canc Ctr, Guangzhou, Peoples R China
[4] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Ultrasound, Guangzhou, Peoples R China
[5] Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA
[6] Sun Yat Sen Univ, Zhongshan Sch Med, Guangzhou, Peoples R China
[7] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Canc Ctr, Dept Breast Canc, Guangzhou, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷
基金：
中国国家自然科学基金;
关键词：
DNA methylation; IRMGs; immune infiltration; prognosis; breast cancer;
D O I：
10.3389/fimmu.2021.704557
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The role of DNA methylation of breast cancer-infiltrating immune cells has not been fully explored. We conducted a cohort-based retrospective study analyzing the genome-wide immune-related DNA methylation of 1057 breast cancer patients from the TCGA cohort and GSE72308 cohort. Based on patients' overall survival (OS), a prognostic risk score system using 18 immune-related methylation genes (IRMGs) was established and further validated in an independent cohort. Kaplan-Meier analysis showed a clear separation of OS between the low- and high-risk groups. Patients in the low-risk group had a higher immune score and stromal score compared with the high-risk group. Moreover, the characteristics based on 18-IRMGs signature were related to the tumor immune microenvironment and affected the abundance of tumor-infiltrating immune cells. Consistently, the 18-IRMGs signatures showed similar influences on immune modulation and survival in another external validation cohort (GSE72308). In conclusion, the proposed 18-IRMGs signature could be a potential marker for breast cancer prognostication.
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页数：12
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