Identification and Validation of Immune-Related Methylation Clusters for Predicting Immune Activity and Prognosis in Breast Cancer

被引：3

作者：

Yang, Anli ^{[1
]}

Zhou, Ying ^{[2
]}

Kong, Yanan ^{[1
]}

Wei, Xiaoli ^{[3
]}

Ye, Feng ^{[1
]}

Zhang, Lijuan ^{[1
]}

Zhong, Xian ^{[4
]}

Li, Mingyue ^{[5
]}

Lu, Shilin ^{[6
]}

An, Xin ^{[3
]}

Xiao, Weikai ^{[1
,7
]}

机构：

[1] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, Dept Breast Oncol, State Key Lab Oncol South China,Canc Ctr, Guangzhou, Peoples R China

[2] Haizhu Dist Ctr Dis Control & Prevent, Dept Infect Dis & Endem Dis Control, Guangzhou, Peoples R China

[3] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, Dept Med Oncol, State Key Lab Oncol South China,Canc Ctr, Guangzhou, Peoples R China

[4] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Ultrasound, Guangzhou, Peoples R China

[5] Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA

[6] Sun Yat Sen Univ, Zhongshan Sch Med, Guangzhou, Peoples R China

[7] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Canc Ctr, Dept Breast Canc, Guangzhou, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷

基金：

中国国家自然科学基金;

关键词：

DNA methylation; IRMGs; immune infiltration; prognosis; breast cancer;

D O I：

10.3389/fimmu.2021.704557

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The role of DNA methylation of breast cancer-infiltrating immune cells has not been fully explored. We conducted a cohort-based retrospective study analyzing the genome-wide immune-related DNA methylation of 1057 breast cancer patients from the TCGA cohort and GSE72308 cohort. Based on patients' overall survival (OS), a prognostic risk score system using 18 immune-related methylation genes (IRMGs) was established and further validated in an independent cohort. Kaplan-Meier analysis showed a clear separation of OS between the low- and high-risk groups. Patients in the low-risk group had a higher immune score and stromal score compared with the high-risk group. Moreover, the characteristics based on 18-IRMGs signature were related to the tumor immune microenvironment and affected the abundance of tumor-infiltrating immune cells. Consistently, the 18-IRMGs signatures showed similar influences on immune modulation and survival in another external validation cohort (GSE72308). In conclusion, the proposed 18-IRMGs signature could be a potential marker for breast cancer prognostication.

引用

页数：12