Efficacy and safety of latanoprost versus travoprost in exfoliative glaucoma patients

Objective: To evaluate 24-hour intraocular pressure (IOP) efficacy of latanoprost versus travoprost, each given every evening, in exfoliative glaucoma patients. Design: Prospective, observer-m asked, crossover comparison. Participants: Forty patients with exfoliation glaucoma. Methods: Patients with a pressure of > 24 mmHg were randomized to latanoprost or travoprost for an 8-week treatment period after a 6-week medicine-free period. Patients were then switched to the opposite treatment for the second period. At untreated baseline and at the end of each treatment period the IOP was measured at 6 AM, 10 AM, 2 Pm, 6 Pm, 10 Pm, and 2 AM. Main Outcome Measure: Diurnal IOP. Results: The mean 24-hour IOP was 25.1 +/- 2.5 mmHg at baseline, 17.8 +/- 2.1 mmHg on latanoprost, and 17.3 +/- 2.2 mmHg on travoprost (P = 0.001). Individual time points were similar between treatments, except at 6 Pm when travoprost provided lower IOP (16.7 +/- 2.6 vs 17.9 +/- 2.5 mmHg, P < 0.001). Adverse events showed more conjunctival hyperemia with travoprost (n = 15) than latanoprost (n = 6; P = 0.03). Conclusions: Latanoprost and travoprost both significantly reduce the 24-hour IOP from baseline in exfoliative glaucoma, but travoprost may demonstrate a greater hypotensive efficacy in the late afternoon.