Acute Respiratory Distress Syndrome: Bench-to-Bedside Approaches to Improve Drug Development

被引：26

作者：

Hussain, Musaddique ^{[1
,2
]}

Xu, Chengyun ^{[1
,2
]}

Ahmad, Mashaal ^{[1
,2
]}

Majeed, Abdul ^{[3
]}

Lu, Meiping ^{[4
]}

Wu, Xiling ^{[4
]}

Tang, Lanfang ^{[4
]}

Wu, Ximei ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Sch Med, Dept Pharmacol, Hangzhou 310058, Zhejiang, Peoples R China

[2] Zhejiang Univ, Sch Med, Key Resp Drug Res Lab China, Food & Drug Adm, Hangzhou 310058, Zhejiang, Peoples R China

[3] Bahauddin Zakariya Univ, Fac Pharm, Multan, Pakistan

[4] Zhejiang Univ, Sch Med, Affiliated Children Hosp, Dept Resp Med, Hangzhou 310006, Zhejiang, Peoples R China

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2018年 / 104卷 / 03期

基金：

中国国家自然科学基金;

关键词：

ACUTE LUNG INJURY; KERATINOCYTE GROWTH-FACTOR; RANDOMIZED CLINICAL-TRIAL; STEM STROMAL CELLS; GENE-THERAPY; HOSPITAL MORTALITY; SEVERE SEPSIS; DOUBLE-BLIND; ARDS; EFFICACY;

D O I：

10.1002/cpt.1034

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Despite 50 years of extensive research, no definite drug is currently available to treat acute respiratory distress syndrome (ARDS), and the supportive therapies remain the mainstay of treatment. To improve drug development for ARDS, researchers need to deeply analyze the omics approaches, reevaluate the suitable therapeutic targets, resolve the problems of inadequate animal modeling, develop the strategies to reduce the heterogeneity, and reconsider new therapeutic and analytical approaches for better designs of clinical trials.

引用

页码：484 / 494

页数：11

共 99 条

[1] Adiponectin Gene Polymorphisms and Acute Respiratory Distress Syndrome Susceptibility and Mortality [J].

Ahasic, Amy M. ;

Zhao, Yang ;

Su, Li ;

Sheu, Chau-Chyun ;

Thompson, B. Taylor ;

Christiani, David C. .

PLOS ONE, 2014, 9 (02)

[2] Reevaluation of the efficacy and safety of the neutrophil elastase inhibitor, Sivelestat, for the treatment of acute lung injury associated with systemic inflammatory response syndrome; a phase IV study [J].

Aikawa, Naoki ;

Ishizaka, Akitoshi ;

Hirasawa, Hiroyuki ;

Shimazaki, Shuji ;

Yamamoto, Yasuhiro ;

Sugimoto, Hisashi ;

Shinozaki, Masahiro ;

Taenaka, Nobuyuki ;

Endo, Shigeatsu ;

Ikeda, Toshiaki ;

Kawasaki, Yasushi .

PULMONARY PHARMACOLOGY & THERAPEUTICS, 2011, 24 (05) :549-554

[3]

ASHBAUGH DG, 1967, LANCET, V2, P319

[4] Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries [J].

Bellani, Giacomo ;

Laffey, John G. ;

Pham, Tai ;

Fan, Eddy ;

Brochard, Laurent ;

Esteban, Andres ;

Gattinoni, Luciano ;

van Haren, Frank ;

Larsson, Anders ;

McAuley, Daniel F. ;

Ranieri, Marco ;

Rubenfeld, Gordon ;

Thompson, B. Taylor ;

Wrigge, Hermann ;

Slutsky, Arthur S. ;

Pesenti, Antonio .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2016, 315 (08) :788-800

[5] The effect of intravenous interferon-beta-1a (FP-1201) on lung CD73 expression and on acute respiratory distress syndrome mortality: an open-label study [J].

Bellingan, Geoff ;

Maksimow, Mikael ;

Howell, David C. ;

Stotz, Martin ;

Beale, Richard ;

Beatty, Monika ;

Walsh, Timothy ;

Binning, Alexander ;

Davidson, Alan ;

Kuper, Martin ;

Shah, Sanjoy ;

Cooper, Jackie ;

Waris, Matti ;

Yegutkin, Gennady G. ;

Jalkanen, Juho ;

Salmi, Marko ;

Piippo, Ilse ;

Jalkanen, Markku ;

Montgomery, Hugh ;

Jalkanen, Sirpa .

LANCET RESPIRATORY MEDICINE, 2014, 2 (02) :98-107

[6] HIGH-DOSE CORTICOSTEROIDS IN PATIENTS WITH THE ADULT RESPIRATORY-DISTRESS SYNDROME [J].

BERNARD, GR ;

LUCE, JM ;

SPRUNG, CL ;

RINALDO, JE ;

TATE, RM ;

SIBBALD, WJ ;

KARIMAN, K ;

HIGGINS, S ;

BRADLEY, R ;

METZ, CA ;

HARRIS, TR ;

BRIGHAM, KL .

NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (25) :1565-1570

[7] THE AMERICAN-EUROPEAN CONSENSUS CONFERENCE ON ARDS - DEFINITIONS, MECHANISMS, RELEVANT OUTCOMES, AND CLINICAL-TRIAL COORDINATION [J].

BERNARD, GR ;

ARTIGAS, A ;

BRIGHAM, KL ;

CARLET, J ;

FALKE, K ;

HUDSON, L ;

LAMY, M ;

LEGALL, JR ;

MORRIS, A ;

SPRAGG, R ;

COCHIN, B ;

LANKEN, PN ;

LEEPER, KV ;

MARINI, J ;

MURRAY, JF ;

OPPENHEIMER, L ;

PESENTI, A ;

REID, L ;

RINALDO, J ;

VILLAR, J ;

VANASBECK, BS ;

DHAINAUT, JF ;

MANCEBO, J ;

MATTHAY, M ;

MEYRICK, B ;

PAYEN, D ;

PERRET, C ;

FOWLER, AA ;

SCHALLER, MD ;

HUDSON, LD ;

HYERS, T ;

KNAUS, W ;

MATTHAY, R ;

PINSKY, M ;

BONE, RC ;

BOSKEN, C ;

JOHANSON, WG ;

LEWANDOWSKI, K ;

REPINE, J ;

RODRIGUEZROISIN, R ;

ROUSSOS, C ;

ANTONELLI, MA ;

BELOUCIF, S ;

BIHARI, D ;

BURCHARDI, H ;

LEMAIRE, F ;

MONTRAVERS, P ;

PETTY, TL ;

ROBOTHAM, J ;

ZAPOL, W .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1994, 149 (03) :818-824

[8] HA-1A IN SEPTIC PATIENTS WITH ARDS - RESULTS FROM THE PIVOTAL TRIAL [J].

BIGATELLO, LM ;

GREENE, RE ;

SPRUNG, CL ;

PANACEK, EA ;

STRAUBE, RC ;

ZIMMERMAN, JL ;

MAUNDER, RJ ;

LANKEN, PN ;

PILESPELLMANN, E ;

STANEK, KS ;

ZASLAVSKY, A ;

ZAPOL, WM .

INTENSIVE CARE MEDICINE, 1994, 20 (05) :328-334

[9] Targeting caspase-1 by inhalation-therapy:: effects of Ac-YVAD-CHO on IL-1β, IL-18 and downstream proinflammatory parameters as detected in rat endotoxaemia [J].

Boost, Kim A. ;

Hoegl, Sandra ;

Hofstetter, Christian ;

Flondor, Michael ;

Stegewerth, Klaus ;

Platacis, Ilka ;

Pfeilschifter, Josef ;

Muhl, Heiko ;

Zwissler, Bernhard .

INTENSIVE CARE MEDICINE, 2007, 33 (05) :863-871

[10]

Brandenberger C., 2016, C30 ACUTE LUNG INJUR

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