An easy access to unsymmetrically substituted 4,4′-bi-1,2,3-triazoles

被引：43

作者：

Fiandanese, Vito ^{[1
]}

Bottalico, Daniela ^{[1
]}

Marchese, Giuseppe ^{[1
]}

Punzi, Angela ^{[1
]}

Capuzzolo, Francesca ^{[1
]}

机构：

[1] Univ Bari, Dipartmento Chim, I-70126 Bari, Italy

来源：

TETRAHEDRON | 2009年 / 65卷 / 51期

关键词：

1,3-DIPOLAR CYCLOADDITIONS; TERMINAL ALKYNES; CLICK CHEMISTRY; 1,2,3-TRIAZOLES; EFFICIENT; AZIDES; LIGATION; POLYMER; WATER;

D O I：

10.1016/j.tet.2009.10.078

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient synthesis of 4-alkynyl-1,2,3-triazoles and novel unsymmetrically substituted 4,4'-bi-1,2,3-triazole derivatives has been devised starting from easily available 1-trimethylsilyi-1,3-butadiyne. The starting compound was reacted with several azides, leading to 4-(silylalkynyl)-1,2,3-triazoles, which were easily transformed into 4-arylalkynyl-1,2,3-triazoles by a Pd catalyzed coupling reaction with aryl halides, or into novel 4,4'-bi-1,2,3-triazole derivatives by a subsequent cyclization reaction with azides. (C) 2009 Elsevier Ltd. All rights reserved.

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页码：10573 / 10580

页数：8

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