Mechanisms of retinal ganglion cell injury and defense in glaucoma

被引：180

作者：

Qu, Juan ^{[1
]}

Wang, Danyi ^{[1
]}

Grosskreutz, Cynthia L. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Ophthalmol, Howe Lab Ophthalmol,Massachusetts Eye & Ear Infir, Boston, MA 02114 USA

来源：

EXPERIMENTAL EYE RESEARCH | 2010年 / 91卷 / 01期

关键词：

apoptosis; neuroprotection; caspase; calcineurin; calpain; NITRIC-OXIDE SYNTHASE; NECROSIS-FACTOR-ALPHA; OPTIC-NERVE DAMAGE; ELEVATED INTRAOCULAR-PRESSURE; CHRONIC OCULAR HYPERTENSION; EARLY GENE-EXPRESSION; OPEN-ANGLE GLAUCOMA; LONG-TERM SURVIVAL; NEUROTROPHIC FACTOR; ADULT-RATS;

D O I：

10.1016/j.exer.2010.04.002

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Glaucoma is a disease in which retinal ganglion cells (RGCs) die leading ultimately to blindness. Over the past decade and a half, information has begun to emerge regarding specific molecular responses of the retina to conditions of elevated intraocular pressure (IOP). It is now clear that the state of the RGC in glaucoma depends on a balance of pro-survival and pro-death pathways in the retina and details of these responses are still being worked out. In this review, we will discuss the evidence supporting the involvement of specific apoptotic cascades as well as the insults that trigger RGC apoptosis. In addition, we will present evidence supporting the existence of endogenous protective mechanisms as well as exogenous neuroprotective strategies. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：48 / 53

页数：6

共 50 条

[41] Glaucoma: from pathogenic mechanisms to retinal glial cell response to damage [J].

Fernandez-Albarral, Jose A. ;

Ramirez, Ana I. ;

de Hoz, Rosa ;

Matamoros, Jose A. ;

Salobrar-Garcia, Elena ;

Elvira-Hurtado, Lorena ;

Lopez-Cuenca, Ines ;

Sanchez-Puebla, Lidia ;

Salazar, Juan J. ;

Ramirez, Jose M. .

FRONTIERS IN CELLULAR NEUROSCIENCE, 2024, 18

[42] Retinal ganglion cells and neuroprotection for glaucoma [J].

Levin, LA .

SURVEY OF OPHTHALMOLOGY, 2003, 48 :S21-S24

[43] Hydrogen sulfide supplement attenuates the apoptosis of retinal ganglion cells in experimental glaucoma [J].

Huang, Shouyue ;

Huang, Ping ;

Lin, Zhongjing ;

Liu, Xiaohong ;

Xu, Xing ;

Guo, Lei ;

Shen, Xi ;

Li, Changwei ;

Zhong, Yisheng .

EXPERIMENTAL EYE RESEARCH, 2018, 168 :33-48

[44] Nitric oxide: A potential mediator of retinal ganglion cell damage in glaucoma [J].

Neufeld, AH .

SURVEY OF OPHTHALMOLOGY, 1999, 43 :S129-S135

[45] Neuroprotection by WldS depends on retinal ganglion cell type and age in glaucoma [J].

Michael L. Risner ;

Silvia Pasini ;

Nolan R. McGrady ;

Karis B. D’Alessandro ;

Vincent Yao ;

Melissa L. Cooper ;

David J. Calkins .

Molecular Neurodegeneration, 16

[46] Neuroprotection by WldS depends on retinal ganglion cell type and age in glaucoma [J].

Risner, Michael L. ;

Pasini, Silvia ;

McGrady, Nolan R. ;

D'Alessandro, Karis B. ;

Yao, Vincent ;

Cooper, Melissa L. ;

Calkins, David J. .

MOLECULAR NEURODEGENERATION, 2021, 16 (01)

[47] Retinal ganglion cell dendrites and glaucoma: a case of missing the wood for the trees? [J].

Chong, Rachel S. ;

Martin, Keith R. .

EXPERT REVIEW OF OPHTHALMOLOGY, 2014, 9 (03) :149-152

[48] Tackling retinal ganglion cell apoptosis in glaucoma: role of adenosine receptors [J].

Agarwal, Puneet ;

Agarwal, Renu .

EXPERT OPINION ON THERAPEUTIC TARGETS, 2021, 25 (07) :585-596

[49] Bax Contributes to Retinal Ganglion Cell Dendritic Degeneration During Glaucoma [J].

Risner, Michael L. ;

Pasini, Silvia ;

McGrady, Nolan R. ;

Calkins, David J. .

MOLECULAR NEUROBIOLOGY, 2022, 59 (03) :1366-1380

[50] Bax Contributes to Retinal Ganglion Cell Dendritic Degeneration During Glaucoma [J].

Michael L. Risner ;

Silvia Pasini ;

Nolan R. McGrady ;

David J. Calkins .

Molecular Neurobiology, 2022, 59 :1366-1380

← 1 2 3 4 5 →