Mechanisms of retinal ganglion cell injury and defense in glaucoma

被引：180

作者：

Qu, Juan ^{[1
]}

Wang, Danyi ^{[1
]}

Grosskreutz, Cynthia L. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Ophthalmol, Howe Lab Ophthalmol,Massachusetts Eye & Ear Infir, Boston, MA 02114 USA

来源：

EXPERIMENTAL EYE RESEARCH | 2010年 / 91卷 / 01期

关键词：

apoptosis; neuroprotection; caspase; calcineurin; calpain; NITRIC-OXIDE SYNTHASE; NECROSIS-FACTOR-ALPHA; OPTIC-NERVE DAMAGE; ELEVATED INTRAOCULAR-PRESSURE; CHRONIC OCULAR HYPERTENSION; EARLY GENE-EXPRESSION; OPEN-ANGLE GLAUCOMA; LONG-TERM SURVIVAL; NEUROTROPHIC FACTOR; ADULT-RATS;

D O I：

10.1016/j.exer.2010.04.002

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Glaucoma is a disease in which retinal ganglion cells (RGCs) die leading ultimately to blindness. Over the past decade and a half, information has begun to emerge regarding specific molecular responses of the retina to conditions of elevated intraocular pressure (IOP). It is now clear that the state of the RGC in glaucoma depends on a balance of pro-survival and pro-death pathways in the retina and details of these responses are still being worked out. In this review, we will discuss the evidence supporting the involvement of specific apoptotic cascades as well as the insults that trigger RGC apoptosis. In addition, we will present evidence supporting the existence of endogenous protective mechanisms as well as exogenous neuroprotective strategies. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：48 / 53

页数：6

共 50 条

[21] Molecular mechanisms of retinal ganglion cell degeneration in glaucoma and future prospects for cell body and axonal protection [J].

Munemasa, Yasunari ;

Kitaoka, Yasushi .

FRONTIERS IN CELLULAR NEUROSCIENCE, 2013, 6

[22] Mechanisms of retinal ganglion cell injury following acute increases in intraocular pressure [J].

Garner, Mary Anne ;

Strickland, Ryan G. ;

Girkin, Christopher A. ;

Gross, Alecia K. .

FRONTIERS IN OPHTHALMOLOGY, 2022, 2

[23] A broad perspective on the molecular regulation of retinal ganglion cell degeneration in glaucoma [J].

Tezel, Gulgun .

GLAUCOMA: A NEURODEGENERATIVE DISEASE OF THE RETINA AND BEYOND - PT A, 2020, 256 :49-77

[24] Cell transplantation approaches to retinal ganglion cell neuroprotection in glaucoma [J].

Johnson, Thomas V. ;

Martin, Keith R. .

CURRENT OPINION IN PHARMACOLOGY, 2013, 13 (01) :78-82

[25] Gene therapy for retinal ganglion cell neuroprotection in glaucoma [J].

A M Wilson ;

A Di Polo .

Gene Therapy, 2012, 19 :127-136

[26] Retinal Ganglion Cell Death in Glaucoma: Advances and Caveats [J].

Yang, Yuting ;

Sun, Xinghuai .

CURRENT EYE RESEARCH, 2023, 48 (01) :1-10

[27] Gene therapy for retinal ganglion cell neuroprotection in glaucoma [J].

Wilson, A. M. ;

Di Polo, A. .

GENE THERAPY, 2012, 19 (02) :127-136

[28] Occurrence of Retinal Ganglion Cell Loss via Autophagy and Apoptotic Pathways in an Autoimmune Glaucoma Model [J].

Reinehr, Sabrina ;

Buschhorn, Verena ;

Mueller-Buehl, Ana M. ;

Goldmann, Tobias ;

Grus, Franz H. ;

Wolfrum, Uwe ;

Dick, H. Burkhard ;

Joachim, Stephanie C. .

CURRENT EYE RESEARCH, 2020, 45 (09) :1124-1135

[29] The molecular mechanisms underlying retinal ganglion cell apoptosis and optic nerve regeneration in glaucoma (Review) [J].

Wang, Xiaotong ;

Sun, Liang ;

Han, Xudong ;

Li, Zhanglong ;

Xing, Yuqing ;

Chen, Xinyue ;

Xi, Ruofan ;

Sun, Yuecong ;

Wang, Guilong ;

Zhao, Ping .

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2025, 55 (04)

[30] Ketorolac Administration Attenuates Retinal Ganglion Cell Death After Axonal Injury [J].

Nadal-Nicolas, Francisco M. ;

Rodriguez-Villagra, Esther ;

Bravo-Osuna, Irene ;

Sobrado-Calvo, Paloma ;

Molina-Martinez, Irene ;

Paz Villegas-Perez, Maria ;

Vidal-Sanz, Manuel ;

Agudo-Barriuso, Marta ;

Herrero-Vanrell, Rocio .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2016, 57 (03) :1183-1192

← 1 2 3 4 5 →