Targets and mechanisms of sulforaphane derivatives obtained from cruciferous plants with special focus on breast cancer - contradictory effects and future perspectives

被引：49

作者：

Kaboli, Parham Jabbarzadeh ^{[1
,2
,3
]}

Khoshkbejari, Masoomeh Afzalipour ^{[4
]}

Mohammadi, Mahsa ^{[5
]}

Abiri, Ardavan ^{[6
]}

Mokhtarian, Roya ^{[3
]}

Vazifemand, Reza ^{[7
]}

Amanollahi, Shima ^{[3
,8
]}

Sani, Shaghayegh Yazdi ^{[3
]}

Li, Mingxing ^{[1
,2
]}

Zhao, Yueshui ^{[1
,2
]}

Wu, Xu ^{[1
,2
]}

Shen, Jing ^{[1
,2
]}

Cho, Chi Hin ^{[1
,2
]}

Xiao, Zhangang ^{[1
,2
]}

机构：

[1] Southwest Med Univ, Sch Pharm, Dept Pharmacol, Lab Mol Pharmacol, Luzhou 646000, Sichuan, Peoples R China

[2] South Sichuan Inst Translat Med, Luzhou 646000, Sichuan, Peoples R China

[3] Parham Acad Biomed Sci, Drug Discovery Res Grp, The Heritage B-16-10, Upm Serdang 43300, Selangor, Malaysia

[4] Islamic Azad Univ, Fac Med, Dept Internal Med, Ardabil Branch, Ardebil, Iran

[5] Islamic Azad Univ, Dept Chem, Cent Tehran Branch, Tehran, Iran

[6] Kerman Univ Med Sci, Fac Pharm, Dept Med Chem, Kerman, Iran

[7] Univ Putra Malaysia, Fac Med & Hlth Sci, Lab Virol, Upm Serdang 43400, Selangor, Malaysia

[8] Univ Florence, Sch Math Phys & Nat Sci, I-50134 Florence, Italy

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2020年 / 121卷

基金：

中国国家自然科学基金;

关键词：

Sulforaphane; Brassicaceae; Breast cancer; nrf2; Apoptosis; INDUCED APOPTOSIS; CHEMOPREVENTIVE ACTIVITY; INHIBITS GROWTH; CELL APOPTOSIS; STEM-CELLS; EXPRESSION; NRF2; ACTIVATION; RESISTANCE; MDA-MB-231;

D O I：

10.1016/j.biopha.2019.109635

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Breast cancer is the most common type of cancer among women. Therefore, discovery of new and effective drugs with fewer side effects is necessary to treat it. Sulforaphane (SFN) is an organosulfur compound obtained from cruciferous plants, such as broccoli and mustard, and it has the potential to treat breast cancer. Hence, it is vital to find out how SFN targets certain genes and cellular pathways in treating breast cancer. In this review, molecular targets and cellular pathways of SFN are described. Studies have shown SFN inhibits cell proliferation, causes apoptosis, stops cell cycle and has anti-oxidant activities. Increasing reactive oxygen species (ROS) produces oxidative stress, activates inflammatory transcription factors, and these result in inflammation leading to cancer. Increasing anti-oxidant potential of cells and discovering new targets to reduce ROS creation reduces oxidative stress and it eventually reduces cancer risks. In short, SFN effectively affects histone deacetylases involved in chromatin remodeling, gene expression, and Nrf2 anti-oxidant signaling. This review points to the potential of SFN to treat breast cancer as well as the importance of other new cruciferous compounds, derived from and isolated from mustard, to target Keap1 and Akt, two key regulators of cellular homeostasis.

引用

页数：17

共 150 条

[1] Computational and biochemical studies of isothiocyanates as inhibitors of proteasomal cysteine deubiquitinases in human cancer cells [J].