Establishment of pediatric reference intervals on a large cohort of healthy children

被引：46

作者：

Southcott, Emma K. ^{[1
]}

Kerrigan, Jennifer L. ^{[1
]}

Potter, Julia M. ^{[1
,2
]}

Telford, Richard D. ^{[2
,3
]}

Waring, Paul ^{[4
]}

Reynolds, Graham J. ^{[2
]}

Lafferty, Antony R. A. ^{[2
]}

Hickman, Peter E. ^{[1
,2
]}

机构：

[1] Canberra Hosp, ACT Pathol, Canberra, ACT, Australia

[2] Australian Natl Univ, Sch Med, Canberra, ACT, Australia

[3] Inst Commonwealth Studies, Canberra, ACT, Australia

[4] Australian Natl Univ, Dept Chem, Canberra, ACT, Australia

来源：

CLINICA CHIMICA ACTA | 2010年 / 411卷 / 19-20期

关键词：

Children; Pediatric; Reference intervals; Biomarkers; CLINICAL-CHEMISTRY; PHYSICAL-ACTIVITY; REFERENCE VALUES; LIFE-STYLE; CONSTITUENTS; CHOLESTEROL; FITNESS; PLASMA; RISK;

D O I：

10.1016/j.cca.2010.06.018

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: Reference intervals are essential in assessing the significance of laboratory results. There have been limited studies generating reference intervals from pediatric populations. We have studied a large cohort of healthy children on 3 separate occasions at 2 yearly intervals. Methods: 852 healthy 8 year old children were enrolled in a community-based multidisciplinary longitudinal study investigating how early physical activity contributes to health. The same children came back for reassessment at ages 10 and 12 years. Blood samples were analyzed for a total of 37 different chemistries, immunoassays or derived values. Results: Reference intervals were derived for all the analytes for males and females separately. Conclusion: Whilst our results are largely in agreement with previously published work, we have shown that for a number of analytes, previously published work is distorted by subclinical disease. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：1421 / 1427

页数：7

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