Netrin G-2 ligand mRNA is downregulated in spinal motoneurons after sciatic nerve lesion

被引：13

作者：

Berg, Alexander ^{[1
]}

Zelano, Johan ^{[1
]}

Cullheim, Staffan ^{[1
]}

机构：

[1] Karolinska Inst, Dept Neurosci, SE-17177 Stockholm, Sweden

来源：

NEUROREPORT | 2010年 / 21卷 / 11期

基金：

瑞典研究理事会;

关键词：

netrin G-2 ligand; peripheral nerve lesion; spinal motoneurons; synaptic adhesion like molecule; synaptic restoration; ADHESION-LIKE MOLECULES; SYNAPSE FORMATION; EXPRESSION; NEUROLIGIN; FAMILY; GAP-43; SYNCAM; AXONS;

D O I：

10.1097/WNR.0b013e32833cadd8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Netrin G-2 ligand (NGL-2) and synaptic adhesion like molecules induce synapses in vitro. We investigated the expression of these molecules in a model of CNS synaptic detachment and restoration in vivo. After axotomy of spinal motoneurons, synapses are lost from the somata of lesioned motoneurons. We could not detect any synaptic adhesion like molecule mRNA in the spinal cord, but signal for NGL-2 mRNA was seen in motoneurons. The signal for NGL-2 decreased after sciatic nerve transection and sciatic nerve crush. After regeneration, the levels of NGL-2 mRNA were partially restored after sciatic nerve transection, but completely restored after sciatic nerve crush. We conclude that axotomized motoneurons decrease their NGL-2 expression and that the restoration of NGL-2 expression mirrors the restoration of synaptic inputs. NeuroReport 21:782-785 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

引用

页码：782 / 785

页数：4

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