Hypospadias: Etiology and Current Research

被引：36

作者：

Kalfa, Nicolas ^{[2
,3
]}

Sultan, Charles ^{[2
,3
]}

Baskin, Laurence S. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Pediat Urol, Ctr Study & Treatment Hypospadias, Parnassus Med Ctr,Childrens Med Ctr, San Francisco, CA 94143 USA

[2] CHU Montpellier, Serv Chirurg & Urol Pediat, Hop Lapeyronie, F-34295 Montpellier 5, France

[3] CHU Montpellier, Serv Hormonol, Hop Lapeyronie, F-34295 Montpellier 5, France

来源：

UROLOGIC CLINICS OF NORTH AMERICA | 2010年 / 37卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Hypospadias; Etiology; Genetics; Sex differentiation disorders; Receptors; Androgen; Environment; ANDROGEN RECEPTOR GENE; WILMS-TUMOR GENE; ACTIVATING TRANSCRIPTION FACTOR-3; LINKED MYOTUBULAR MYOPATHY; ESTROGEN-RESPONSIVE GENES; FOOT-GENITAL SYNDROME; SONIC-HEDGEHOG; CANDIDATE GENES; REPRODUCTIVE FUNCTION; EXTERNAL GENITALIA;

D O I：

10.1016/j.ucl.2010.03.010

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Hypospadias is one of the most common congenital defects in humans. The molecular events required in the genitourinary tract for normal development of the external genitalia are just beginning to be elucidated. Identifying the cause of hypospadias may be relevant not only in the field of pediatric urology, but also for worldwide public health. This article discusses the possible causes of hypospadias and the genes and growth factors involved. The potential effects of genetic susceptibility and environmental pollutants are also discussed.

引用

页码：159 / +

页数：9

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