Hypospadias: Etiology and Current Research

被引：36
作者：
Kalfa, Nicolas [2 ,3 ]
Sultan, Charles [2 ,3 ]
Baskin, Laurence S. [1 ]
机构：
[1] Univ Calif San Francisco, Dept Pediat Urol, Ctr Study & Treatment Hypospadias, Parnassus Med Ctr,Childrens Med Ctr, San Francisco, CA 94143 USA
[2] CHU Montpellier, Serv Chirurg & Urol Pediat, Hop Lapeyronie, F-34295 Montpellier 5, France
[3] CHU Montpellier, Serv Hormonol, Hop Lapeyronie, F-34295 Montpellier 5, France
来源：
UROLOGIC CLINICS OF NORTH AMERICA | 2010年 / 37卷 / 02期
基金：
美国国家卫生研究院;
关键词：
Hypospadias; Etiology; Genetics; Sex differentiation disorders; Receptors; Androgen; Environment; ANDROGEN RECEPTOR GENE; WILMS-TUMOR GENE; ACTIVATING TRANSCRIPTION FACTOR-3; LINKED MYOTUBULAR MYOPATHY; ESTROGEN-RESPONSIVE GENES; FOOT-GENITAL SYNDROME; SONIC-HEDGEHOG; CANDIDATE GENES; REPRODUCTIVE FUNCTION; EXTERNAL GENITALIA;
D O I：
10.1016/j.ucl.2010.03.010
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Hypospadias is one of the most common congenital defects in humans. The molecular events required in the genitourinary tract for normal development of the external genitalia are just beginning to be elucidated. Identifying the cause of hypospadias may be relevant not only in the field of pediatric urology, but also for worldwide public health. This article discusses the possible causes of hypospadias and the genes and growth factors involved. The potential effects of genetic susceptibility and environmental pollutants are also discussed.
引用
收藏
页码：159 / +
页数：9
相关论文
共 100 条
[1]   Estrogen receptor-α and β are differentially distributed, expressed and activated in the fetal genital tubercle [J].
Agras, Koray ;
Willingham, Emily ;
Shiroyanagi, Yoshiyuki ;
Minasi, Petros ;
Baskin, Laurence S. .
JOURNAL OF UROLOGY, 2007, 177 (06) :2386-2392
[2]   Prevalence of hypospadias and other genital anomalies among singleton births, 1988-1997, in Scotland [J].
Ahmed, SF ;
Dobbie, R ;
Finlayson, AR ;
Gilbert, J ;
Youngson, G ;
Chalmers, J ;
Stone, D .
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 2004, 89 (02) :149-151
[3]   Is the incidence of hypospadias increasing? Analysis of Finnish hospital discharge data 1970-1994 [J].
Aho, M ;
Koivisto, AM ;
Tammela, TLJ ;
Auvinen, A .
ENVIRONMENTAL HEALTH PERSPECTIVES, 2000, 108 (05) :463-465
[4]   The roles of ATF3 in glucose homeostasis - A transgenic mouse model with liver dysfunction and defects in endocrine pancreas [J].
Allen-Jennings, AE ;
Hartman, MG ;
Kociba, GJ ;
Hai, T .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (31) :29507-29514
[5]   Linkage between cryptorchidism, hypospadias, and GGN repeat length in the androgen receptor gene [J].
Aschim, EL ;
Nordenskjöld, A ;
Giwercman, A ;
Lundin, KB ;
Ruhayel, Y ;
Haugen, TB ;
Grotmol, T ;
Giwercman, YL .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (10) :5105-5109
[6]   INCIDENCE OF HYPOSPADIAS IN SWEDEN [J].
AVELLAN, L .
SCANDINAVIAN JOURNAL OF PLASTIC AND RECONSTRUCTIVE SURGERY AND HAND SURGERY, 1975, 9 (02) :129-139
[7]   Genetic polymorphisms of ESR1 and ESR2 that may influence estrogen activity and the risk of hypospadias [J].
Ban, Susumu ;
Sata, Fumihiro ;
Kurahashi, Norie ;
Kasai, Setsuko ;
Moriya, Kimihiko ;
Kakizaki, Hidehiro ;
Nonomura, Katsuya ;
Kishi, Reiko .
HUMAN REPRODUCTION, 2008, 23 (06) :1466-1471
[8]   The novel contiguous gene syndrome of myotubular myopathy (MTM1), male hypogenitalism and deletion in Xq28: report of the first familial case [J].
Bartsch, O ;
Kress, W ;
Wagner, A ;
Seemanova, E .
CYTOGENETICS AND CELL GENETICS, 1999, 85 (3-4) :310-314
[9]  
Bates PA, 2001, PROTEINS, P39
[10]   Activating transcription factor 3:: a hormone responsive gene in the etiology of hypospadias [J].
Beleza-Meireles, Ana ;
Tohonen, Virpi ;
Soderhall, Cilla ;
Schwentner, Christian ;
Radmayr, Christian ;
Kockum, Ingrid ;
Nordenskjold, Agneta .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2008, 158 (05) :729-739
12345678910